2nd G-NMR School

Kontakt:

Christian Richter

Announcement

G-NMR School, 29.02. - 4.3.2016
Goethe-University Frankfurt
Campus Riedberg, N100 (B1 - B3)
Max-von-Laue-Str. 9
60438 Frankfurt

Introduction

From February 29th to March 4th 2016, the 2nd G-NMR school will be held at the Goethe-University in Frankfurt. The aim of the course is to familiarize PhD students and postdocs with basic theoretical NMR knowledge and state-of-the-art experimental approaches. During the first three days of the course participants will be introduced to the theoretical fundamentals of NMR spectroscopy. This will not only include lectures but will also be supplemented with exercise sessions. A basic understanding of NMR is required in order to be able to follow the lectures. The second part is scheduled in parallel sessions for specific topics:

Biomolecular solution NMR
Solid state NMR
NMR on small molecules, polymere and metabolomics

In addition, the participants will be trained at the spectrometer in practical sessions.

All aspects of modern NMR spectroscopy including biomolecular solution NMR, solid-state NMR and NMR on “small molecules” will be covered in the general sessions. This general part of the G-NMR school will provide the theoretical fundamentals of NMR spectroscopy. It includes the introduction in to the concept of product operator formalism, relaxation and solid state NMR, as well as implementation of phase cycling, quadrature detection and TROSY in multi-dimensional experiments. The topics will be further discussed in greater detail in smaller groups within the exercise sessions.

Parallel session one will cover state-of-the-art methods in biomolecular NMR: general aspects of 2D and 3D NMR, as well as assignment experiments for protein and RNA molecules, measurement of residual dipolar coupling (RDC), relaxation dispersion and paramagnetic relaxation enhancement (PRE), strategies to analyze and quantify ligand binding, and modelling of protein structures employing NMR restraints. It will also cover practical aspects of pulse sequence programming.

The content of session two are all methods and new experiments developed for solid state NMR.

The third session will provide an insight into the aspects of NMR on “small molecules” including experiments for pure shift phase, strategy for assignment and methods for structure elucidation. The course will also introduce metabolomics, working with NMR-shift database and polymers.

Speakers

The following lecturers have agreed to give presentations:

Johanna Becker-Baldus, Universität Frankfurt
Monika Beerbaum, FMP Berlin
Wolfgang Bermel, Bruker Biospin Rheinstetten
Gerd Buntkowsky, TU Darmstadt
Teresa Carlomagno, Universität Hannover
Björn Corzilius, Universität Frankfurt
Elke Duchardt-Ferner, Universität Frankfurt
Boris Fürtig, Universität Frankfurt
Gerd Gemmecker, TU München
Steffen Glaser, TU München
Clemens Glaubitz, Universität Frankfurt
Christian Griesinger, MPI Göttingen
Peter Güntert, Universität Frankfurt
Thomas Hackl, Universität Hamburg
Henry Jonker, Universität Frankfurt
Matthias Köck, AWI Bremerhaven
Adam Lange, FMP Berlin
Johannes Liermann, Univerität Mainz
Burkhard Luy, KIT Karlsruhe
Jiafei Mao, Universität Frankfurt
Philipp Neudecker, FZ Jülich / HHU Düsseldorf
Bernd Reif, TU München
Christian Richter, Universität Frankfurt
Kay Saalwächter, Universität Halle
Michael Sattler, TU München
Ulrich Scheler, Leibnitz Institut Dresden
Nils Schlörer, Universität Köln
Jörn Schmedt auf der Günne, Universität Siegen
Peter Schmieder, FMP Berlin
Harald Schwalbe, Universität Frankfurt
Christina Thiele, TU Darmstadt
Julia Wirmer-Bartoschek, Universität Frankfurt
Jens Wöhnert, Universität Frankfurt
Markus Zweckstetter, MPI Göttingen / Universität Göttingen

Program

General part for all participants

	Monday, 29.2.		Tuesday, 1.3.	Wednesday, 2.3.
8:30 – 10:30	Product Operators I Steffen Glaser		Anisotropic Interactions Bernd Reif	Solid-state NMR I Clemens Glaubitz
10:30 – 11:00	Coffee Break
11:00 – 13:00	Product Operators II Christian Griesinger		Relaxation I Harald Schwalbe	Solid-state NMR II Clemens Glaubitz
13:00 – 14:00	Lunch
14:00 – 16:00	Exercise I in groups Monika Beerbaum, Elke Duchardt-Ferner, Boris Fürtig, Julia Wirmer-Bartoschek		Exersise II in groups Monika Beerbaum, Elke Duchardt-Ferner, Boris Fürtig, Julia Wirmer-Bartoschek	Exercise III Johanna Becker-Baldus
16:00 – 16:30	Coffee Break
16:30 – 18:30	Phase Cycling / Gradients / Quadrature Peter Schmieder		Relaxation II Harald Schwalbe	TROSY & Cross-Correlated Relaxation Christian Griesinger
18:30			Bier & Snacks	Dinner Mensa
19:30 -		Discussion of the Exercise I & II

Parallel Session: Bio-NMR

	Thursday, 3.3.	Friday, 4.3.
8:30 – 9:30	2D and 3D NMR Michael Sattler	Pulse Programming Wolfgang Bermel
9:30 – 10:30	NMR on Proteins Michael Sattler	Pulse Programming Wolfgang Bermel
10:30 – 11:00	Coffee Break
11:00 – 13:00	Partial Alignment of Molecules Markus Zweckstetter	Relaxation Dispersion Experiments Philipp Neudecker
11:00 – 13:00	Partial Alignment of Molecules Markus Zweckstetter	NMR on RNA Jens Wöhnert
13:00 – 14:00	Lunch
14:00 – 16:00	NMR in drug design Teresa Carlomagno	Structural Analysis Peter Güntert
16:00 – 16:30	Coffee Break
16:30 – 18:30	A: Exercise at Spectrometer in 3 groups Wolfgang Bermel, Gerd Gemmecker, Christian Richter B: Introduction to NMR spectra analysis Henry Jonker	A: Exercise at Spectrometer in 3 groups Wolfgang Bermel, Gerd Gemmecker, Christian Richter B: Exercise structure calculation Henry Jonker

Parallel Session: Solid State NMR

	Thursday, 3.3.	Friday, 4.3.
9:00 – 10:30	Protons in solid-state NMR Bernd Reif	Theory of Dynamic Nuclear Polarisation Björn Corzilius
9:30 – 10:30	Protons in solid-state NMR Bernd Reif	Theory of Dynamic Nuclear Polarisation Björn Corzilius
10:30 – 11:00	Coffee Break
11:00 – 12:30	Transversal Relaxation in solid-state NMR Kay Saalwächter	AHT and Symmetries: C and R Sequence Jörn Schmedt auf der Günne
12:30 – 13:30	Lunch
13:30 – 15:00	Quantitative Distance Measurements Gerd Buntkowsky	13:30 – 14:30 Praxis of DNP and further tricks to reduce NMR time Jiafei Mao / Glaubitz Lab
15:00 – 15:15	Short break
15:15 – 16:45	Protein solid-state NMR: Resonance assignment and detection of distance restraints Adam Lange	14:45 – 15:30 Lab Demo: DNP-enhanced MAS Jiafei Mao / Glaubitz Lab
16:45 – 17:00	Short break	END
17:00 – 18:00	Introduction to Quadropole solid-state NMR Gerd Buntkowsky	END

Parallel Session: small Molecules

	Thursday, 3.3.	Friday, 4.3.
8:30 – 9:30	Overview: NMR-Experiments for Small Molecules Johannes Liermann	Sequential assignment of peptides Monika Beerbaum
9:30 – 10:30	Homonuclear Decoupling Wolfgang Bermel	Metabolomics Thomas Hackl
10:30 – 11:00	Coffee Break
11:00 – 13:00	Exercise at Spectrometer in 3 groups Wolfgang Bermel, Johannes Liermann, Christian Richter	Exercise at Spectrometer in 3 groups Wolfgang Bermel, Johannes Liermann, Christian Richter
13:00 – 14:00	Lunch
14:00 – 15:00	2D Experiments (coupling constants /Fast 2D Experiments) Burkhard Luy	NMR database for assignment control Nils Schlörer
15:00 – 16:00	RDCs Christina Thiele	Macromolecules, size, binding and charge from PFG NMR Ulrich Scheler
16:00 – 16:30	Coffee Break
16:30 – 18:30	Natural products / structure elucidation 1 (incl. exercise) Matthias Köck	Natural products / structure elucidation 2 (incl. exercise) Matthias Köck

Attachments:

Program 2nd G-NMR school

Password protected page

Venue

Goethe-University / Campus Riedberg

Biocenter (Building N100)

Lecture Hall B1, B2, B3

Marie-Curie-Straße 9

60439 Frankfurt am Main

Map Campus Riedberg

Attachments:

3D Map Campus Riedberg (PDF)

Map Campus Riedberg (PDF)

Registration

G-NMR School, 29.02. - 4.3.2016
Goethe-University Frankfurt
Campus Riedberg, N100 (B1 - B3)
Max-von-Laue-Str. 9

60438 Frankfurt

Link to Registration Form

The Registration is closed. The maximum number of participants is reached.

Registration Fees

only the theoretical part of the G-NMR School (29.2-2.3.2016)	Registration Fee: 70,- €
the complete G-NMR Summer School (29.2-4.3.2016)	Registration Fee: 100,- €