Summary
NMR is in principle able to probe at atomic level the structural characteristics of the different states of a protein en route on the pathways of folding, misfolding or aggregation. (Figure 1)
The UPMAN project aims to study structural states of proteins, ranging from highly flexible unfolded monomers to soluble oligomers and precursors of fibrillar aggregates, relevant to understanding protein misfolding and aggregation.
Novel NMR and computational tools will be developed able to investigate the disorganised ensembles characteristic of some of the most interesting and biologically relevant species.
This project is supported through Priority 1 (Life Sciences, Genomics and Biotechnology for Health) of European Union's FP6.
Project full title: Understanding Protein Misfolding and Aggregation by NMR
Contract number: LSHG-CT-2004-512052.
