Bachelor Thesis in the AK Schwalbe

Research in AK Schwalbe is focused on the determination of structure and function of molecules including small molecule ligands, RNA, DNA, proteins (in solution and in the membrane). In order to do so, chemical and biochemical synthesis, NMR spectroscopy, MD simulations are applied. Of particular interest are time-resolved studies of protein and RNA folding, which are studied by CD, fluorescence and NMR spectroscopy. Collaborative projects with the groups of Prisner, Wachtveitl, Stock, Glaubitz, Heckel, and Göbel are also possible. Signing for a Bachelor thesis at the beginning of a semester is mandatory.

Title Language Tutor J-Coupling Analysis in Short Peptides EN, DE Daniel Mathieu NMR and CD Spectroscopic Investigations of Prion Peptide Fragments EN Jitendra Kumar Proteinfaltung EN, DE Kai Schlepckow Spektroskopische (NMR, CD) Untersuchungen der Wechselwirkungen von nicht-natürlichen Peptiden mit der TAR-RNA (HIV-1, HIV-2) EN, DE Jan Ferner Unambiguous Assignment of both Iterations of the Lanthanide binding Motif in double-LBT-Ubiquitin EN, DE Martin Hähnke NMR Assignment and Structural Calculations of Biologically Relevant Small Molecules EN Dr. Henry Jonker & Sridhar Sreeramulu Solution Phase Peptide Synthesis of Small Hydrophobic Peptides and their Characterization by 1H NMR Spectroscopy EN Dr. Raja Karuppiah Conformational Analysis of Antibiotic Mini-Membrane Protein Gramicidin A Analogs in Membrane Mimicking Environments by 1H NMR Spectroscopy EN Dr. Raja Karuppiah Synthesis of Small Peptides Containing cis-Proline Analogs and NMR Characterization EN Dr. Raja Karuppiah Dynamic NMR Analysis of Small Nucleotides and Their Energetics in Solution EN Dr. Raja Karuppiah Chemical Synthesis of LD Peptides and Their NMR Analysis EN Dr. Raja Karuppiah Database Analysis of Protein Structures Solved by NMR Spectroscopy EN Dr. Raja Karuppiah Structural and Conformational Analysis of Tryptophan Rich Motifs in High Resolution Protein Structures EN Dr. Raja Karuppiah Biochemical Synthesis and subsequent NMR-Spectroscopic Characterization of a Trypanosome Binding RNA Aptamer Mutant EN, DE Jörg Rinnenthal