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Protein folding and misfolding

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Regarding protein folding, we are able to analyse the starting point of folding, the unfolded state of proteins, by NMR spectroscopy (Klein-Seetharaman et al., Science 2002) as well as kinetics of folding and misfolding (Schlepckow et al., Angew. Chem. 2013) and the structure of the folded state.