Publications

Found 355 results

2018

Dutta D, Debnanth M, Müller D, Paul R, Das T, Bessi I, Schwalbe H, Dash J. 2018. Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex. Nucl. Acids Res.. 46:5355-5365.

Keyhani S, Goldau T, Blümler A, Heckel* A, Schwalbe* H. 2018. Chemo-enzymatic synthesis of position-specifically modified RNA for biophysical studies including light control and NMR spectroscopy. Angew. Chem. Int. Ed..

Bains JK, Blechar J, de Jesus V, Meiser N, Fürtig B, Schwalbe H, Hengesbach M. 2018. Combined smFRET and NMR analysis of riboswitch structural dynamics. Methods.

Qureshi NS, Sreeramulu S, Bains JK, Schwalbe* H, Fürtig* B. 2018. Conformational switch in the ribosomal protein S1 guides unfolding of structured RNAs for translation initiation. Nucl. Acids Res..

Niesteruk A, Jonker HRA, Richter C, Linhardt V, Sreeramulu S, Schwalbe H. 2018. The domain architecture of the PtkA, the first tyrosine kinase from Mycobacterium tuberculosis differs from the conventional kinase architecture. J. Biol. Chem..

Coutinho ID, Henning LMM, Döpp SA, Mepomuceno A, Morales LAC, Marcolino-Gomes J, Richter C, Schwalbe H, Colnago LA. 2018. Flooded soybean metabolomic analysis reveals important primary and secondary metabolites involved in the hypoxia stress response and tolerance. Environmental and Experimental Biology. 153:176-187.

Shi YM, Richter C, Challinor VL, Grün P, GirelaDelRio A, Kaiser M, SChüffler A, Piepenbring M, Schwalbe H, Bode HB. 2018. Georatusin, a Specific Antiparasitic Polyketide-Peptide Hybrid from the Fungus Geomyces auratus. Org Lett. 20:1563-1567.

Maiti S, Saha P, Das T, Bessi I, Schwalbe H, Dash J. 2018. Human Telomeric G-quadruplex Selective Fluoro-isoquinolines Induce Apoptosis in Cancer Cells. Bioconjugate Chemistry. 29(4):1141-1154.

Rehbein P, Schwalbe H. 2018. Improved high-yield expression, purification and refolding of recombinant mammalian prion proteins under aerosol-free elevated biological safety conditions. Protein Expr Purif. 150:53-60.

Muthukumar Y, Münkemer J, Mathieu D, Richter C, Schwalbe H, Steinmetz H, Kessler W, Reichelt J, Beutling U, Frank R et al.. 2018. Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria. PLOS One.

Helmling C, Klötzner D, Sochor F, Mooney RA, Wacker A, Landick R, Fürtig B, Heckel A, Schwalbe H. 2018. Life times of metastable states guide regulatory signaling in transcriptional riboswitches. Nat. Commun.. 9:944.

Raab M, Sanhaji M, Pietsch L, Béquignon I, Herbrand AK, Süß E, Gande SL, Caspar B, Kudlinzki D, Saxena K et al.. 2018. Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds. ACS Chem Biol.

Joedicke L, Mao J, Kuenze G, Reinhart C, Kalavacherla T, Jonker HRA, Richter C, Schwalbe H, Meiler J, Preu J et al.. 2018. The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.. Nat. Chem. Biol.. 14:284-290.

Elamri I, Heumüller M, Herzig LM, Stirnal E, Wachtveitl J, Schuman E, Schwalbe H. 2018. A new photocaged puromycin for an efficient labelling of newly translated proteins in living neurons. ChemBioChem.

Tröster A, Heinzlmeir S, Berger BT, Gande SL, Saxena K, Sreeramulu S, Linhard V, Nasiri AH, Bolte M, Müller S et al.. 2018. NVP-BHG712: Effects of regioisomers on the affinity and selectivity towards the EPHrin family. ChemMedChem.

Wienen-Schmidt B, Wulsdorf T, Jonker HRA, Saxena K, Kudlinzki D, Linhard V, Sreeramulu S, Heine A, Schwalbe H, Klebe G. 2018. On the implication of water on fragment-to-ligand growth in kinase binding thermodynamics. ChemMedChem.

Seyfried P, Heinz M, Pintér G, Klötzner DP, Becker Y, Bolte M, Jonker HRA, Stelzl L, Hummer G, Schwalbe* H et al.. 2018. Optimal destabilization of DNA double strands by single-nucleobase caging. Chemistry.

Wienen-Schmidt B, Jonker HRA, Wulsdorf T, Gerber H-D, Saxena K, Kudlinzki D, Sreeramulu S, Parigi G, Luchinat C, Heine A et al.. 2018. Paradoxically, Most Flexible Ligand Binds Most Entropy-Favored: Intriguing Impact of Ligand Flexibility and Solvation on Drug-Kinase Binding. J. Med. Chem..

Debnath M, Ghosh S, Panda D, Bessi I, Schwalbe H, Bhattacharyya K, Dash J. 2018. Small molecule regulated dynamic structural changes of human G-quadruplexes. Chem. Sci.. 7:3279-3285.

Kappert F, Sreeramulu S, Jonker HRA, Richter C, Rogov VV, Proschak E, Hargittay B, Saxena K, Schwalbe H. 2018. Structural Characterization of the Interaction of the Fibroblast Growth Factor Receptor with a Small Molecule Allosteric Inhibitor. Chemistry - A European Journal. 24:7861-7865.

Niesteruk A, Hutchison M, Sreeramulu S, Jonker HRA, Richter C, Abele R, Bock C, Schwalbe H. 2018. Structural characterization of the Intrinsically Disordered Domain (IDD) of Mycobacterium tuberculosis Protein Tyrosine Kinase A (PtkA). FEBS Lett.. 592(7):1233-1245.

Garcia-Lopez A, Tessaro F, Jonker HRA, Wacker A, Richter C, Comte A, Berntenis N, Schmucki R, Hatje K, Petermann O et al.. 2018. Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes. Nat. Commun..

2017

Heinzlmeir S, Lohse J, Treiber T, Kudlinzki D, Linhardt V, Gande SL, Sreeramulu S, Saxena K, Liu X, Wilhelm M et al.. 2017. Chemoproteomics-aided medicinal chemistry for the discovery of EPHA2 inhibitors. ChemMedChem. 12(12):999-1011.

Barthelmes D, Barthelmes K, Schnorr K, Jonker HRA, Bodmer B, Allen KN, Imperiali B, Schwalbe H. 2017. Conformational dynamics and alignment properties of lopp Lanthanide-Binding-Tags (LBTs) studied in Interleukin-1beta. J. Biomol. NMR. 68(3):187-194.

Schnieders R, Richter C, Warhaut S, de Jesus V, Keyhani S, Duchardt-Ferner E, Keller H, Wöhnert J, Kuhn LT, Breeze AL et al.. 2017. Evaluation of 15N-detected H-N correlation experiments on increasingly large RNAs. J. Biomol. NMR. 69:31-44.

Lehner F, Kudlinzki D, Richter C, Müller-Werkmeister H, Eberl K, Bredenbeck J, Schwalbe* H, Silvers* R. 2017. The Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding. ChemBioChem. 18:2340-2350.

Schnorr K, Gophane DB, Helmling C, Cetiner E, Pasemann K, Fürtig B, Wacker A, Qureshi NS, Gränz M, Barthelmes D et al.. 2017. Impact of spin label rigidity on extent and accuracy of distance information from PRE data. J. Biomol. NMR. 68(1):53-63.

Nasiri HR, Hohmann K, Hatemler M, Schwalbe H. 2017. In vitro production of reactive oxygen species (ROS) by sampangine. Med. Chem. Res.. 26:1170-1175.

Lannes L, Young P, Richter C, Morgner N, Schwalbe H. 2017. Interaction of the N-Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA Sequence. ChemBioChem. 18(20):2033-2044.

Kim YB, Wacker A, von Laer K, Rogov V, Suess B, Schwalbe H. 2017. Ligand binding to 2’-deoxyguanosine sensing riboswitch in metabolic context. Nucl. Acids Res.. 45(9):5375-5386.

Warhaut S, Mertinkus KR, Höllthaler P:, Fürtig B, Heilemann M, Hengesbach M, Schwalbe H. 2017. Ligand-modulated folding of the full-length adenine riboswitch probed by NMR and single-molecule FRET spectroscopy. Nucl. Acids Res.. 45:5512-5522.

Herzig' L-M, Elamri' I, Schwalbe* H, Wachtveitl* J. 2017. Light-induced antibiotic release from a coumarin-caged compound on the ultrafast timescale. Phys Chem Chem Phys. 19(22):14835-14844.

Liu Y, Sharp JS, Do DH, Kahn RA, Schwalbe H, Buhr F, Prestegard J. 2017. Mistakes in translation: Reflections on mechanism.. PLoS One. 12(6 ):e0180566.

Joedicke L, Mao J, Kuenze G, Reinhart C, Kalavacherla T, Jonker HRA, Richter C, Schwalbe H, Meiler J, Preu J et al.. 2017. The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors. Nat. Chem. Biol..

Schwalbe H. 2017. New 1.2 GHz NMR spectrometers - new horizons? Angew. Chem. Int. Ed.. 56:10252-10253.

Wirmer-Bartoschek J, Bendel LE, Jonker HRA, Grün JT, Papi F, Bazzicalupi C, Messori L, Gratteri* P, Schwalbe* H. 2017. The NMR solution structure of a ligand/hybrid-2-G-quadruplex complex reveals structural rearrangements that facilitate ligand binding. Angew. Chem. Intl. Ed.. 56:7102-7106.

Helmling C, Wacker A, Wolfinger MT, Hofacker IL, Hengesbach M, Fürtig B, Schwalbe H. 2017. NMR structural profiling of transcriptional intermediates reveals riboswitch regulation by metastable RNA conformations. J. Am. Chem. Soc.. 139(7):2647-2656.

Steinert' H, Sochor' F, Wacker A, Buck J, Helmling C, Hiller F, Keyhani S, Noeske J, Grimm S, Rudolph MM et al.. 2017. Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation. eLife. :e21297.

DiGuiseppi D, Milorey B, Lewis G, Kubatova N, Farrell S, Schwalbe H, Schweitzer-Stenner R. 2017. Probing the Conformation Dependent Preferential Binding of Ethanol to Cationic Glycylalanylglycine in Water/Ethanol by Vibrational and NMR Spectroscopy. J. Chem. Phys.. 121(23):5744-5758.

Hutchison M, Schwalbe H. 2017. Protein misfolding. Modern Magnetic Resonance: 2nd edition.

Cai X, Shi YM, Pöhlmann N, Revermann O, Bahner I, Pidot SJ, Wesche F, Lackner H, Büchel C, Kaiser M et al.. 2017. Structure and Biosynthesis of Isatropolones, Bioactive Amine-Scavenging Fluorescent Natural Products from Streptomyces Gö66.. Angew. Chem. Intl. Ed.. 56:4945-4949.

Bessi I, Wirmer-Bartoschek J, Dash J, Schwalbe H. 2017. Targeting G-quadruplex with small molecules: an NMR view. Modern Magnetic Resonance: 2nd edition.

Pinter G, Schwalbe H. 2017. Unprecedented carbon signal enhancement in liquid-state NMR spectroscopy. Angew, Chem. Int. Ed. . 56(29):8332-8334.

2016

Sochor F, Silvers R, Müller D, Richter C, Fürtig B, Schwalbe H. 2016. 19F-labeling of the adenine H2-site to study large RNAs by NMR spectroscopy.. J Biomol NMR. 64(1):63-74.

Grothe J, Krysciak D, Petersen K, Güllert S, Förstner KU, Krishnan HB, Schwalbe H, Kubatova N, Streit W. 2016. The Absence of the N-acyl-homoserine-lactone Autoinducer Synthase Genes traI and ngrI Increases the Copy Number of the Symbiotic Plasmid in Sinorhizobium fredii NGR234. Front. Microbiol.. 7:1858.

Stellos K, Gatsiou A, Stamatelopoulos K, Matic LP, John D, Lunella FF, Jaé N, Rossbach O, Amrhein C, Sigala F et al.. 2016. Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.. Nat. Medicine. 22:1140-1150.

Nasiri AH, Saxena K, Bats JW, Nasiri HR, Schwalbe H. 2016. Biophysical investigation and conformational analysis of p38α kinase inhibitor doramapimod and its analogues. MedChemCom. 7:1421-1428.

Heinzlmeir# S, Kudlinzki# D, Sreeramulu S, Klaeger S, Gande SL, Linhardt V, Wilhelm M, Qiao H, Helm D, Ruprecht B et al.. 2016. Chemical proteomics and structural biology define EPHA2 inhibition by clinical kinase drugs.. ACS Chem. Biol..

Hahn J, Thalmann S, Migur A, von Boeselager FR, Kubatova N, Kubareva E, Schwalbe H, Evguenieva-Hackenberg E. 2016. Conserved small mRNA with an unique, extended Shine-Dalgarno sequence. RNA Biol..

Fürtig B, Schnieders R, Richter C, Zetzsche H, Keyhani S, Helmling C, Kovacs H, Schwalbe H. 2016. Direct 13C-detected NMR Experiments for Mapping and Characterization of Hydrogen Bonds in RNA. J. Biomol. NMR. 64(3):207-21.