Publications

Found 482 results

2024
Krause NM, Bains JK, Blechar J, Richter C, Bessi I, Grote P, Leisegang MS, Brandes* RP, Schwalbe* H.  2024.  Biophysical investigation of RNA-DNA:DNA triple helix and RNA:DNA heteroduplex formation by the lncRNAs MEG3 and Fendrr. ChemBioChem.
Jalencas X, Berg H, Espeland LO, Sreeramulu S, Kinnen F, Richter C, Georgiou C, Yadrykhinsky V, Specker E, Jaudzems K et al..  2024.  Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection. RSC Med. Chem..
Lala B, Chaudhuri R, Prasanth T, Burkhart I, Schwalbe H, Dash J.  2024.  Guanosine-based hydrogel as a supramolecular scaffold for template-assisted macrocylization. Chem. Commun. . 60:3433-3436.
Matzel T, Martin WM, Herr A, Wacker A, Richter C, Sreeramulu S, Schwalbe H.  2024.  NMR characterization and ligand binding site of the stem loop 2 motif (s2m) from the Delta variant of SARS-CoV-2.. RNA.
Ugrina M, Burkhart I, Müller D, Schwalbe H, Schwierz N.  2024.  RNA G-quadruplex folding is a multi-pathway process driven by conformational entropy. Nucl. Acids Res.. 52:87-100.
Blechar J, de Jesus V, Fürtig B, Hengesbach* M, Schwalbe* H.  2024.  Shine-Dalgarno accessibility governs ribosome binding to the adenine riboswitch. ACS Chem. Biol.. 19:607-618.
Vögele J, Duchardt-Ferner E, Bains JK, Knezic B, Wacker A, Sich C, Weigand J, Sponer J, Schwalbe H, Krepl M et al..  2024.  Structure of an internal loop motif with three consecutive U•U mismatches from stem-loop 1 in the 3'-UTR of the SARS-CoV-2 genomic RNA. Nucl. Acids Res..
Altincekic* N, Jores N, Löhr F, Richter C, Ehrhardt C, Blommers MJJ, Berg H, Öztürk S, Gande SL, Linhard V et al..  2024.  Targeting main protease (Mpro, nsp5) by growth of fragment scaffolds exploiting structure-based methodologies. ACS Chem. Biol. . 19:563-574.
2023
Bains KJ, Qureshi N, Ceylan B, Wacker A, Schwalbe H.  2023.  Cell-free transcription-translation system – A dual read-out assay to characterize riboswitch function. Nucl. Acids Res. 51, e82. Nucl. Acids Res.. 51:e82.
Üresin D, Pyper DJ, Borst A, Hadjeres L, Gelhausen R, Backofen R, Sharma C, Schwalbe H, Soppa J.  2023.  Characterization of the zinc finger µ-protein HVO_0758 from Haloferax volcanii: biological roles, zinc binding, and NMR solution structure. Frontiers in Microbiology. 14:120972.
Tannenberg R, Paul M, Röder B, Gande SL, Sreeramulu S, Saxena K, Richter C, Schwalbe H, Swart C, Weller MG.  2023.  Chemiluminescence Biosensor for the Determination of Cardiac Troponin I (cTNI). Biosensors. 13:455.
Duchardt-Ferner E, Ferner J, Fürtig B, Hengesbach M, Richter C, Schlundt A, Sreeramulu S, Wacker A, Weigand JE, Wirmer-Bartoschek J et al..  2023.  COVID19-NMR consortium: A public report on the impact of this new global collaboration. Angew. Chem. Intl. Ed.. :e202217171.
Li Y, Pustovalova Y, Shi W, Gorbatyuk O, Sreeramulu S, Schwalbe H, Hoch JC, Hao B.  2023.  Crystal structure of the CoV-Y domain of SARS-CoV-2 nonstructural protein 3.. Sci Rep.. 13(1):2890.
Ali T, Rogala S, Krause N, Bains KJ, Melissari M-T, Währisch S, Schwalbe H, Herrmann BG, Grothe P.  2023.  Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA Triplex Element. Nucl. Acids Res.
Vögele J, Hymon D, Martins J, Ferner J, Jonker HRA, Hargrove AE, Wacker A, Schwalbe H, Wöhnert J, Duchardt-Ferner E.  2023.  High-resolution structure of stem-loop 4 from the 5'-UTR of SARS-CoV-2 solved by solution state NMR. Nucl. Acids Res.. 51:11318-11331.
Grün JT, Kim J, Jayanthi S, Lupulescu A, Kupče ER, Schwalbe H, Frydman L.  2023.  Identifying and Overcoming Artifacts in 1H-Based Saturation Transfer NOE NMR Experiments. J. Am. Chem. Soc..
Oxenfarth A, Kümmerer F, Battaro S, Schnieders R, Pinter G, Jonker HRA, Fürtig B, Richter C, Blackledge M, Lindorff-Larsen K et al..  2023.  Integrated NMR/Molecular Dynamics Determination of the Ensemble Conformation of a thermodynamically stable CUUG RNA tetraloop. JACS. 145:16557-16572.
Cherepanov AV, Schwalbe H.  2023.  Large Temperature-Jump and Nanosecond Hyperquenching for Time-Resolve Structural Studies. Chemistry Method.
Kunert S, Linhard V, Weidrich S, Choudalakis M, Osswald F, Krämer L, Köhler AR, Bröhm A, Wollenhaupt J, Schwalbe H et al..  2023.  The MECP2-TRD domain interacts with the DNMT3A-ADD domain at the H3-tail binding site. Protein Sci. 32(1):e4542.
Hutchison M, Bellomo G, Cherepanov A, Stirnal E, Fürtig B, Richter C, Linhard V, Gurewitsch E, Lelli M, Morgner N et al..  2023.  Modulation of Aβ42 aggregation kinetics and pathway by low molecular weight inhibitors. ChemBioChem.
Hymon D, Martins J, Richter C, Sreeramulu S, Wacker A, Ferner J, Patwarhan NN, Hargroove AE, Schwalbe H.  2023.  NMR 1H, 19F-based screening of the four stem-looped structure 5_SL1-SL4 located in the 5’-untranslated region of SARS-CoV-2 RNA.. RSC Med. Chem. . 15:165-177.
Tröster A, DiPrima M, Jores N, Kudlinzki D, Sreeramulu S, Gande SL, Linhard V, Ludig D, Schug A, Saxena K et al..  2023.  Optimization of the Lead Compound NVP-BHG712 as Colorectal Cancer Inhibitor. Chemistry - A European Journal.
Alshamleh I, Kurrle N, Makowka P, Bhayadia R, Kumar R, Süsser S, Seibert M, Ludig D, Wolf S, Koschade SE et al..  2023.  PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia. Leukemia. 37:2367-2382.
Sudakov A, Knezic B, Hengesbach M, Fürtig B, Stirnal E, Schwalbe H.  2023.  Site-Specific Labeling of RNAs with Modified and 19F-Labelled Nucleotides by Chemo-Enzymatic Synthesis. Chemistry.
2022
Mertinkus KR, Grün JT, Altincekic N, Bains KJ, Ceylan B, Ferner J-P, Frydman L, Fürtig B, Hengesbach M, Hohmann KF et al..  2022.  1H, 13C and 15N chemical shift assignment of the stem-loops 5b+c from the 5'-UTR of SARS-CoV-2. Biomolecular NMR Assignments. 16(1):17-25.
Tsika AC, Gallo A, Fourkiotis NK, Argyriou AI, Sreeramulu S, Löhr F, Rogov VV, Richter C, Linard V, Gande SL et al..  2022.  Binding adaptation of GS-441524 diversifies macro domains and downregulate SARS-CoV-2 de-MARylation capacity. J. Mol. Biol.. 434(16):167720.
Landgraf T, Völklein AE, Fürtig* B, Schwalbe* H.  2022.  The cotranscriptional folding landscape for two cyclic di-nucleotide-sensing riboswitches with highly homologous aptamer domains acting either as ON- or OFF-switches. Nucl. Acids Res. 50(12):6639-55.
Cunningham A, Erdem A, Alshamleh I, Geugien M, Pruis M, Pereira-Martins DA, van den Heuvel F, Wierenga A, Berge THA, Dennebos R et al..  2022.  Dietary methionine starvation impairs acute myeloid leukemia progression. Blood.
Berg H, Martin WMA, Altincekic N, Alshamleh I, Bains KJ, Blechar J, Ceylan B, de Jesus V, Dhamotharan K, Fuks C et al..  2022.  Exploring the druggability of conserved RNA regulatory elements in the SARS-CoV-2 genome. Angew. Chem. Intl. Ed.. 61:e202205858.
Kim J, Novakovic M, Jayanthi S, Lupulescu A, Kupce E, Grün T, Mertinkus K, Oxenfarth A, Schwalbe H, Frydman L.  2022.  The Extended Hadamard Transform: Sensitivity-Enhanced NMR Experiments Among Labile and Non-Labile 1Hs of SARS-CoV-2-derived RNAs. ChemPhysChem.
Leisegang MS, Bains KJ, Seredinski S, Oo LA, Krause NM, Kuo C-C, Günther S, Cetin NS, Warwick T, Cao C et al..  2022.  HIF1alpha-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex. Nat. Commun. 13( 6563)
Knezic B, Keyhani-Goldau S, Schwalbe H.  2022.  Mapping the conformational landscape of the neutral network of RNA sequences that connect two functional distinctly different ribozymes. ChemBioChem. 23(7):e202200022.
Heering J, Jores N, Kilu W, Schallmayer E, Peelen E, Muehler A, Kohlhof H, Vitt D, Linhard V, Gande SL et al..  2022.  Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators . ACS CHem. Biol..
Niesteruk A, Sreeramulu S, Jonker HRA, Richter C, Schwalbe H.  2022.  Oxidation of the Mycobacterium tuberculosis key virulence factor protein tyrosine phosphatase A (MptpA) reduces its phosphatase activity.. Febs Lett..
Schweizer-Stenner* R, Milorey B, Schwalbe* H.  2022.  Randomizing of oligopeptide conformations by nearest neighbor interactions between amino acids. Biomolecules. 12:684.
Blümler A, Schwalbe* H, Heckel* A.  2022.  Solid-Phase-Supported Chemoenzymatic Synthesis of a Light-Activatable tRNA Derivative.. Angew. Chem. Intl. Ed.. 61:e202111613.
Broft P, Rosenkranz R, Schleiff E, Hengesbach* M, Schwalbe* H.  2022.  Structural analysis of temperature-dependent alternative splicing of HsfA2 pre-mRNA from tomato plants. RNA Biology. 19:266-278.
Schamber T, Binas O, Schlundt A, Wacker A, Schwalbe H.  2022.  Structure and Dynamics of the Guanidine-II Riboswitch from Escherichia coli by NMR Spectroscopy and Small-angle X-ray Scattering (SAXS). ChemBioChem. 23:e20210056410.
Warwick T, Serendinski S, Krause NM, Bains KJ, LAthaus L, Oo JA, Bonetti A, Dueck A, Engelhardt S, Schwalbe H et al..  2022.  A universal model of RNA.DNA:DNA triplex formation accurately predicts genome-wide RNA-DNA interactions . Brief Bioinform. bbac445
2021
Gallo A, Tsika AC, Fourkiotis NK, Cantini F, Banci L, Sreeramulu S, Schwalbe H, Spyroulias GA.  2021.  1H, 13C and 15N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: "the N-terminal domain-SUD-N".. Biomolecular NMR assignments. 15:85-89. Abstract
Vögele J, Ferner J-P, Altincekic N, Bains KJ, Ceylan B, Fürtig B, Grün JT, Hengesbach M, Hohmann KF, Hymon D et al..  2021.  1H, 13C, 15N and 31P chemical shift assignment for stem-loop 4 from the 5'-UTR of SARS-CoV-2. Biomolecular NMR assignments. 15:335-340.
Richter C, K. F. Hohmann, S. Toews MADN, Toews S, Mathieu D, Altincekic N, Bains KJ, Binas O, Ceylan B, Duchardt-Ferner E, Ferner J et al..  2021.  1H, 13C, and 15N Assignment of Stem-Loop SL1 from the 5'-UTR of SARS-CoV-2. Biomolecular NMR assignments. 15(2):467-474.
Salvi N, Bessa LM, Guseva S, Camcho-Zarco A, Maurin D, Perez LM, Hengesbach M, Korn SM, Schlundt A, Schwalbe H et al..  2021.  1H, 13C, and 15N backbone chemical shift assignments of SARS-CoV-2 Nsp3a. Biomolecular NMR assignments. 15:173-176.
Wang Y, Kirkpatrick J, zur Lage S, Korn SM, Neißner K, Schwalbe H, Schlundt A, Carlomagno T.  2021.  1H, 13C, and 15N backbone chemical-shift assignments of SARS-CoV-2 non-structural protein 1 (leader protein). Biomolecular NMR assignments. 15:287-295.
Schnieders R, Peters SA, Banijamali E, Riad M, Altincekic N, Bains JK, Ceylan B, Fürtig B, Grün JT, Hengesbach M et al..  2021.  1H, 13C, and 15N chemical shift assignments of the stem-loop 5a from the 5‘-UTR of SARS-CoV-2. Biomolecular NMR assignments.
Kim J, Novakovic M, Jayanthi S, Lupulescu A, Kupce E, Grün JT, Mertinkus K, Oxenfarth A, Richter C, Schnieders R et al..  2021.  3D Heteronuclear Magnetization Transfers for the establishment of secondary structures in SARS-CoV-2-derived RNAs. J. Am. Chem. Soc. 143:4942-4948.
Dudás FE, Puglisi R, Korn SM, Alfano C, Bellone ML, Piaz FD, Kelly G, Monaca E, Schlundt A, Schwalbe H et al..  2021.  Backbone chemical shift spectral assignments of SARS coronavirus-2 non-structural protein nsp9.. Biomolecular NMR assignments. 15:235-241.
Sreeramulu S, Richter C, Berg H, Martin WMA, Ceylan B, Matzel T, Adam J, Altincekic N, Azzaoui K, Bains KJ et al..  2021.  Exploring the druggability of conserved RNA regulatory elements in the SARS-CoV-2 genome. Angew. Chem. Int. Ed. Engl.. 60:19191-19200.
Grün JT, Schwalbe H.  2021.  Folding Dynamics of Polymorphic G-Quadruplex Structures. Biopolymers.
Müller D, Bessi I, Richter C, Schwalbe H.  2021.  The folding landscapes of human telomeric RNA and DNA G-quadruplexes are markedly different.. Angew. Chem. Int. Ed. Engl.. 60(19):10895-10901.