Publications

Found 487 results

2020
Sreeramulu S, Richter C, Kühn T, Azzaoui K, Blommers MJJ, Conte DR, Fragai M, Trieloff N, Schmieder P, Nazaré M et al..  2020.  NMR Quality Control of Fragment Libraries for Screening. J. Biomol. NMR. 74:555-563.
Schnieders R, Knezic B, Zetzsche H, Sudakov A, Matzel T, Richter C, Hengesbach M, Schwalbe H, Fürtig B.  2020.  NMR spectroscopy of large functional RNAs - from sample preparation to low-gamma-detection. Current protocols in Nucl. Acids. 82(e116)
Wenger KJ, Richter C, Burger MC, Urbans H, Kaulfuss S, Jarter PN, Sreeramulu S, Schwalbe H, Steinbach JP, Hattingen E et al..  2020.  Non-invasive measurement of drug a 2-HG signals using 19F and 1H MR spectroscopy in brain tumors treated with the mutant IDH1 inhibitor BAY1436032.. Cancers. 12:E3175.
Neuber C, Tröster A, Löser R, Belter B, Schwalbe H, Pietzsch J.  2020.  The Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitor NVP-BHG712: Effects of Regioisomers on Tumor Growth, Perfusion, and Hypoxia in EphB4-Positive A375 Melanoma Xenografts.. Molecules. 25(21):E5115.
Parra-Rojas C, Fürtig B, Schwalbe H, Esteban H-V.  2020.  Quantitative modeling of the function of kinetically driven transcriptional riboswitches. J. Theor. Biol.. 505:110406.
Aslamleh I, Krause N, Richter C, Kurrle N, Serve H, Günther UL, Schwalbe H.  2020.  Real-time NMR for studying metabolism. Angew. Chem. Int. Ed. Engl.. 59(6):2304-2308.
Pinter G, Schwalbe H.  2020.  Refolding of cold denatured barstar induced by radio frequency heating – new method to study protein folding by real-time NMR spectroscopy. Angew. Chem. Int. Ed. Engl..
Fürtig B, Oberhauser EM, Zetzsche H, Klötzner DP, Heckel A, Schwalbe H.  2020.  Refolding through a linear transition state enables fast temperature adaptation of a translational riboswitch. Biochemistry. 59(10):1081-1086.
Wacker A, Weigand JE, Akabayov S-R, Altincekic N, Bains JK, Banijamali E, Binas O, Castillo-Martínez J, Cetiner E, Ceylan B et al..  2020.  Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy. Nucl. Acids Res. 48(22):12415-12435.
Novakovic M, Kupče Ē, Oxenfarth A, Battistel MD, Freedberg DI, Schwalbe H, Frydman L.  2020.  Sensitivity enhancement of homonuclear multidimensional NMR correlations for labile sites in proteins, polysaccharides, and nucleic acids. Nat. Comm. 11 (1):5317.
Altincekic N, Löhr M, Meier-Credo J, Langer J, Hengesbach M, Richter C, Schwalbe H.  2020.  Site-specific detection of arginine methylation in highly repetitive protein motifs of low sequence complexity by NMR. J. Am. Chem. Soc. 142(16):7647-7654.
Heiliger J, Matzel T, Cetiner EC, Schwalbe* H, Kuenze* G, Corzilius B.  2020.  Site-specific dynamic nuclear polarization in a Gd(III)-labeled protein. Chem. Phys. Phys. Chem..
Zhou S, Ruan M, Li Y, Yang J, Bai S, Richter C, Schwalbe H, Xie C, Shen B, Wang J.  2020.  Solution structure of the voltage-gated Tim23 channel in complex with a mitochondrial presequence peptide . Cell Res.
Binas O, Tants JN, Peters S, Janowski R, Davydova E, Braun J, Niessing D, Schwalbe H, Weigand J, Schlundt A.  2020.  Structural basis for the recognition of transiently structured AU-rich elements by Roquin. Nucl. Acids Res.. 48(13):7385-7403.
Lieblein T, Zangl R, Martin J, Hoffmann J, Hutchinson M, Stark T, Stirnal E, Schrader T, Schwalbe H, Morgner N.  2020.  Structural Rearrangement of Amyloid-beta upon Inhibitor Binding Suppresses Formation of Alzheimer's Disease Related Oligomers. eLife. 9:e59306.
Binas O, Bessi I, Schwalbe H.  2020.  Structure validation for G-rich RNAs in non-coding regions of the human genome. ChemBioChem. 21(11):1656-1663.
Weigand JE, Ferner J, Fürtig B, Hacker C, Hähnke M, Hengesbach M, Richter C, Saxena K, Schlundt A, Sreeramulu S et al..  2020.  Strukturbiologie von SARS-CoV-2 mit NMR-Spektroskopie. Nachrichten aus Chemie und Technik. 68:55-58.
Elamri I, Radloff M, Hohmann KF, Nimbarte VD, Nasiri HR, Bolte M, Safarian S, Michel H, Schwalbe H.  2020.  Synthesis and biological screening of new lawson derivatives as selective substrate-based inhibitors of cytochrome bo3 ubiquinol oxidase from Escherichia coli.. ChemMedChem. 15:1262-1271.
2019
Shi YN, Pusch S, Shi YM, Richter C, Macia-Vicente JG, Schwalbe H, Kaiser M, Opatz T, Bode HB.  2019.  (±) Alternarlactones A and B, two antiparasitic alternariol-like dimers from the fungus Alternaria alternate P1210 isolated from the halophyte Salicornia sp.. J. Org. Chem.. 84(17):11203-11209.
Rehbein* P, Berz J, Kreisel P, Schwalbe H.  2019.  Codon Wizard – An intuitive software tool for customizable codon optimization in protein expression efforts with graphical user interface.. Protein Expr Purif.. 19:S1046-5928.
Bains JK, Blechar J, de Jesus V, Meiser N, Fürtig B, Schwalbe H, Hengesbach M.  2019.  Combined smFRET and NMR analysis of riboswitch structural dynamics. Methods. S1046-2023(18):30303-7.
Rehbein P, Raguz N, Schwalbe H.  2019.  Evaluating mechanical properties of silica-coated alginate beads for immobilized biocatalysis. Biochemical Engineering Journal . 141:225-231.
Saha P, Kumar YP, Das T, Müller D, Bessi I, Schwalbe H, Das J.  2019.  A G-quadruplex Specific Cell-Permeable Guanosine-Anthracene Conjugate Inhibits Telomere Elongation and Induces Apoptosis by Repressing c-MYC Gene. Bioconjugate Chem.. 30(12):3038-3045.
DiPrima M, Wang D, Tröster A, Maric D, Terrades-Garcia N, Ha T, Kwak H, Sanchez-Martin D, Kudlinzki D, Schwalbe H et al..  2019.  Identification of Eph receptor signaling as a regulator of autophagy and a therapeutic target in colorectal carcinoma.. Mol. Oncol.. 13(11):2441-2459.
Kreitz J, Schönfeld C, Seibert M, Stolp V, Alshamleh I, Oellerich T, Steffen B, Schwalbe H, Schnütgen F, Kurrle N et al..  2019.  Metabolic Plasticity of Acute Myeloid Leukemia. Cells. 8(8):E805.
Reese M, George C, Yang C, Jawla S, Grün TJ, Schwalbe H, Redfield C, Temkin RJ, Griffin RG.  2019.  Modular, triple-resonance, transmission line DNP MAS probe for 500 MHz/330 GHz. J. Magn. Reson.. 307:106573.
Merk* D, Sreeramulu S, Kudlinzki D, Saxena K, Linhardt V, Gande SL, Hiller F, Lamers C, Nilsson E, Aagard A et al..  2019.  Molecular tuning of farnesoid X receptor partial agonism. Nature Comm.. 10(1):2915.
Schnieders R, Keyhani S, Schwalbe* H, Fürtig* B.  2019.  More than Proton Detection – New Avenues for NMR of RNA. Chemistry. 26(1):102-111.
Schnieders R, Wolter AC, Richter C, Wöhnert J, Schwalbe* H, Fürtig* B.  2019.  Novel 13C-detected NMR experiments for precise detection of RNA structure. Angew. Chem. Int. Ed.. 58(27):9140-9144.
Cetiner EC, Jonker HRA, Helmling C, Gophane DB, Grünewald C, Sigurdsson ST, Schwalbe H.  2019.  Paramagnetic-Iterative Relaxation Matrix Approach – Extracting PRE-Restraints from NOESY Spectra for 3D Structure Elucidation of Biomolecules. J. Biomol. NMR. 73(12):699-712.
Kubatova N, Pyper DJ, Jonker HRA, Saxena K, Remmel L, Richter C, Brantl S, Evguenieva-Hackenberg E, Hess W, Klug G et al..  2019.  Rapid biophysical characterization and NMR structural analysis ofsmall proteins from bacteria and archaea. ChemBioChem.
Kubatova N, Jonker HRA, Saxena K, Richter C, Vogel V, Schreiber S, Marchfelder A, Schwalbe H.  2019.  Solution structure and dynamics of the small protein HVO_2922 from Haloferax volcanii. ChemBioChem. 21(1-2):149-156.
2018
Dutta D, Debnanth M, Müller D, Paul R, Das T, Bessi I, Schwalbe H, Dash J.  2018.  Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex. Nucl. Acids Res.. 46:5355-5365.
Keyhani S, Goldau T, Blümler A, Heckel* A, Schwalbe* H.  2018.  Chemo-enzymatic synthesis of position-specifically modified RNA for biophysical studies including light control and NMR spectroscopy. Angew. Chem. Int. Ed.. 57:12017-12021.
Qureshi NS, Sreeramulu S, Bains JK, Schwalbe* H, Fürtig* B.  2018.  Conformational switch in the ribosomal protein S1 guides unfolding of structured RNAs for translation initiation. Nucl. Acids Res.. 46:10917-10929.
Niesteruk A, Jonker HRA, Richter C, Linhardt V, Sreeramulu S, Schwalbe H.  2018.  The domain architecture of the PtkA, the first tyrosine kinase from Mycobacterium tuberculosis differs from the conventional kinase architecture. J. Biol. Chem.. 293 :11823-11836.
Coutinho ID, Henning LMM, Döpp SA, Mepomuceno A, Morales LAC, Marcolino-Gomes J, Richter C, Schwalbe H, Colnago LA.  2018.  Flooded soybean metabolomic analysis reveals important primary and secondary metabolites involved in the hypoxia stress response and tolerance. Environmental and Experimental Biology. 153:176-187.
Shi YM, Richter C, Challinor VL, Grün P, GirelaDelRio A, Kaiser M, SChüffler A, Piepenbring M, Schwalbe H, Bode HB.  2018.  Georatusin, a Specific Antiparasitic Polyketide-Peptide Hybrid from the Fungus Geomyces auratus. Org Lett. 20:1563-1567.
Maiti S, Saha P, Das T, Bessi I, Schwalbe H, Dash J.  2018.  Human Telomeric G-quadruplex Selective Fluoro-isoquinolines Induce Apoptosis in Cancer Cells. Bioconjugate Chemistry. 29(4):1141-1154.
Coutinho ID, Henning LMM, Döpp SA, Nepomuceno A, Moraes LAC, Marcolino-Gomes J, Richter C, Schwalbe H, Colnago LA.  2018.  Identification of primary and secondary metabolites and transcriptome profile of soybean tissues during different stages of hypoxia. Data Brief. 21:1089-1100.
Rehbein P, Schwalbe H.  2018.  Improved high-yield expression, purification and refolding of recombinant mammalian prion proteins under aerosol-free elevated biological safety conditions. Protein Expr Purif. 150:53-60.
Muthukumar Y, Münkemer J, Mathieu D, Richter C, Schwalbe H, Steinmetz H, Kessler W, Reichelt J, Beutling U, Frank R et al..  2018.  Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria. PLOS One. 13:e0201605.
Helmling C, Klötzner D, Sochor F, Mooney RA, Wacker A, Landick R, Fürtig B, Heckel A, Schwalbe H.  2018.  Life times of metastable states guide regulatory signaling in transcriptional riboswitches. Nat. Commun.. 9:944.
Raab M, Sanhaji M, Pietsch L, Béquignon I, Herbrand AK, Süß E, Gande SL, Caspar B, Kudlinzki D, Saxena K et al..  2018.  Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds. ACS Chem Biol. 13:1921-1931.
Joedicke L, Mao J, Kuenze G, Reinhart C, Kalavacherla T, Jonker HRA, Richter C, Schwalbe H, Meiler J, Preu J et al..  2018.  The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.. Nat. Chem. Biol.. 14:284-290.
Elamri I, Heumüller M, Herzig LM, Stirnal E, Wachtveitl J, Schuman E, Schwalbe H.  2018.  A new photocaged puromycin for an efficient labelling of newly translated proteins in living neurons. ChemBioChem. 19:2358-2464.
Tröster A, Heinzlmeir S, Berger BT, Gande SL, Saxena K, Sreeramulu S, Linhard V, Nasiri AH, Bolte M, Müller S et al..  2018.  NVP-BHG712: Effects of regioisomers on the affinity and selectivity towards the EPHrin family. ChemMedChem. 13:2358-2464.
Wienen-Schmidt B, Wulsdorf T, Jonker HRA, Saxena K, Kudlinzki D, Linhard V, Sreeramulu S, Heine A, Schwalbe H, Klebe G.  2018.  On the implication of water on fragment-to-ligand growth in kinase binding thermodynamics. ChemMedChem. 13:1988-1996.
Seyfried P, Heinz M, Pintér G, Klötzner DP, Becker Y, Bolte M, Jonker HRA, Stelzl L, Hummer G, Schwalbe* H et al..  2018.  Optimal destabilization of DNA double strands by single-nucleobase caging. Chemistry. 24:17568-17576.
Wienen-Schmidt B, Jonker HRA, Wulsdorf T, Gerber H-D, Saxena K, Kudlinzki D, Sreeramulu S, Parigi G, Luchinat C, Heine A et al..  2018.  Paradoxically, Most Flexible Ligand Binds Most Entropy-Favored: Intriguing Impact of Ligand Flexibility and Solvation on Drug-Kinase Binding. J. Med. Chem.. 61:5922-5933.