Publications

Found 439 results

2018
Seyfried P, Heinz M, Pintér G, Klötzner DP, Becker Y, Bolte M, Jonker HRA, Stelzl L, Hummer G, Schwalbe* H et al..  2018.  Optimal destabilization of DNA double strands by single-nucleobase caging. Chemistry. 24:17568-17576.
Wienen-Schmidt B, Jonker HRA, Wulsdorf T, Gerber H-D, Saxena K, Kudlinzki D, Sreeramulu S, Parigi G, Luchinat C, Heine A et al..  2018.  Paradoxically, Most Flexible Ligand Binds Most Entropy-Favored: Intriguing Impact of Ligand Flexibility and Solvation on Drug-Kinase Binding. J. Med. Chem.. 61:5922-5933.
Debnath M, Ghosh S, Panda D, Bessi I, Schwalbe H, Bhattacharyya K, Dash J.  2018.  Small molecule regulated dynamic structural changes of human G-quadruplexes. Chem. Sci.. 7:3279-3285.
Kappert F, Sreeramulu S, Jonker HRA, Richter C, Rogov VV, Proschak E, Hargittay B, Saxena K, Schwalbe H.  2018.  Structural Characterization of the Interaction of the Fibroblast Growth Factor Receptor with a Small Molecule Allosteric Inhibitor. Chemistry - A European Journal. 24:7861-7865.
Niesteruk A, Hutchison M, Sreeramulu S, Jonker HRA, Richter C, Abele R, Bock C, Schwalbe H.  2018.  Structural characterization of the Intrinsically Disordered Domain (IDD) of Mycobacterium tuberculosis Protein Tyrosine Kinase A (PtkA). FEBS Lett.. 592(7):1233-1245.
Garcia-Lopez A, Tessaro F, Jonker HRA, Wacker A, Richter C, Comte A, Berntenis N, Schmucki R, Hatje K, Petermann O et al..  2018.  Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes. Nat. Commun..
2017
Heinzlmeir S, Lohse J, Treiber T, Kudlinzki D, Linhardt V, Gande SL, Sreeramulu S, Saxena K, Liu X, Wilhelm M et al..  2017.  Chemoproteomics-aided medicinal chemistry for the discovery of EPHA2 inhibitors. ChemMedChem. 12(12):999-1011.
Barthelmes D, Barthelmes K, Schnorr K, Jonker HRA, Bodmer B, Allen KN, Imperiali B, Schwalbe H.  2017.  Conformational dynamics and alignment properties of lopp Lanthanide-Binding-Tags (LBTs) studied in Interleukin-1beta. J. Biomol. NMR. 68(3):187-194.
Schnieders R, Richter C, Warhaut S, de Jesus V, Keyhani S, Duchardt-Ferner E, Keller H, Wöhnert J, Kuhn LT, Breeze AL et al..  2017.  Evaluation of 15N-detected H-N correlation experiments on increasingly large RNAs. J. Biomol. NMR. 69:31-44.
Lehner F, Kudlinzki D, Richter C, Müller-Werkmeister H, Eberl K, Bredenbeck J, Schwalbe* H, Silvers* R.  2017.  The Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding. ChemBioChem. 18:2340-2350.
Schnorr K, Gophane DB, Helmling C, Cetiner E, Pasemann K, Fürtig B, Wacker A, Qureshi NS, Gränz M, Barthelmes D et al..  2017.  Impact of spin label rigidity on extent and accuracy of distance information from PRE data. J. Biomol. NMR. 68(1):53-63.
Nasiri HR, Hohmann K, Hatemler M, Schwalbe H.  2017.  In vitro production of reactive oxygen species (ROS) by sampangine. Med. Chem. Res.. 26:1170-1175.
Lannes L, Young P, Richter C, Morgner N, Schwalbe H.  2017.  Interaction of the N-Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA Sequence. ChemBioChem. 18(20):2033-2044.
Kim YB, Wacker A, von Laer K, Rogov V, Suess B, Schwalbe H.  2017.  Ligand binding to 2’-deoxyguanosine sensing riboswitch in metabolic context. Nucl. Acids Res.. 45(9):5375-5386.
Warhaut S, Mertinkus KR, Höllthaler P:, Fürtig B, Heilemann M, Hengesbach M, Schwalbe H.  2017.  Ligand-modulated folding of the full-length adenine riboswitch probed by NMR and single-molecule FRET spectroscopy. Nucl. Acids Res.. 45:5512-5522.
Herzig' L-M, Elamri' I, Schwalbe* H, Wachtveitl* J.  2017.  Light-induced antibiotic release from a coumarin-caged compound on the ultrafast timescale. Phys Chem Chem Phys. 19(22):14835-14844.
Liu Y, Sharp JS, Do DH, Kahn RA, Schwalbe H, Buhr F, Prestegard J.  2017.  Mistakes in translation: Reflections on mechanism.. PLoS One. 12(6 ):e0180566.
Joedicke L, Mao J, Kuenze G, Reinhart C, Kalavacherla T, Jonker HRA, Richter C, Schwalbe H, Meiler J, Preu J et al..  2017.  The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors. Nat. Chem. Biol..
Schwalbe H.  2017.  New 1.2 GHz NMR spectrometers - new horizons? Angew. Chem. Int. Ed.. 56:10252-10253.
Wirmer-Bartoschek J, Bendel LE, Jonker HRA, Grün JT, Papi F, Bazzicalupi C, Messori L, Gratteri* P, Schwalbe* H.  2017.  The NMR solution structure of a ligand/hybrid-2-G-quadruplex complex reveals structural rearrangements that facilitate ligand binding. Angew. Chem. Intl. Ed.. 56:7102-7106.
Helmling C, Wacker A, Wolfinger MT, Hofacker IL, Hengesbach M, Fürtig B, Schwalbe H.  2017.  NMR structural profiling of transcriptional intermediates reveals riboswitch regulation by metastable RNA conformations. J. Am. Chem. Soc.. 139(7):2647-2656.
Steinert' H, Sochor' F, Wacker A, Buck J, Helmling C, Hiller F, Keyhani S, Noeske J, Grimm S, Rudolph MM et al..  2017.  Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation. eLife. :e21297.
DiGuiseppi D, Milorey B, Lewis G, Kubatova N, Farrell S, Schwalbe H, Schweitzer-Stenner R.  2017.  Probing the Conformation Dependent Preferential Binding of Ethanol to Cationic Glycylalanylglycine in Water/Ethanol by Vibrational and NMR Spectroscopy. J. Chem. Phys.. 121(23):5744-5758.
Hutchison M, Schwalbe H.  2017.  Protein misfolding. Modern Magnetic Resonance: 2nd edition.
Cai X, Shi YM, Pöhlmann N, Revermann O, Bahner I, Pidot SJ, Wesche F, Lackner H, Büchel C, Kaiser M et al..  2017.  Structure and Biosynthesis of Isatropolones, Bioactive Amine-Scavenging Fluorescent Natural Products from Streptomyces Gö66.. Angew. Chem. Intl. Ed.. 56:4945-4949.
Bessi I, Wirmer-Bartoschek J, Dash J, Schwalbe H.  2017.  Targeting G-quadruplex with small molecules: an NMR view. Modern Magnetic Resonance: 2nd edition.
Pinter G, Schwalbe H.  2017.  Unprecedented carbon signal enhancement in liquid-state NMR spectroscopy. Angew, Chem. Int. Ed. . 56(29):8332-8334.
2016
Sochor F, Silvers R, Müller D, Richter C, Fürtig B, Schwalbe H.  2016.  19F-labeling of the adenine H2-site to study large RNAs by NMR spectroscopy.. J Biomol NMR. 64(1):63-74.
Grothe J, Krysciak D, Petersen K, Güllert S, Förstner KU, Krishnan HB, Schwalbe H, Kubatova N, Streit W.  2016.  The Absence of the N-acyl-homoserine-lactone Autoinducer Synthase Genes traI and ngrI Increases the Copy Number of the Symbiotic Plasmid in Sinorhizobium fredii NGR234. Front. Microbiol.. 7:1858.
Stellos K, Gatsiou A, Stamatelopoulos K, Matic LP, John D, Lunella FF, Jaé N, Rossbach O, Amrhein C, Sigala F et al..  2016.  Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.. Nat. Medicine. 22:1140-1150.
Nasiri AH, Saxena K, Bats JW, Nasiri HR, Schwalbe H.  2016.  Biophysical investigation and conformational analysis of p38α kinase inhibitor doramapimod and its analogues. MedChemCom. 7:1421-1428.
Heinzlmeir# S, Kudlinzki# D, Sreeramulu S, Klaeger S, Gande SL, Linhardt V, Wilhelm M, Qiao H, Helm D, Ruprecht B et al..  2016.  Chemical proteomics and structural biology define EPHA2 inhibition by clinical kinase drugs.. ACS Chem. Biol..
Hahn J, Thalmann S, Migur A, von Boeselager FR, Kubatova N, Kubareva E, Schwalbe H, Evguenieva-Hackenberg E.  2016.  Conserved small mRNA with an unique, extended Shine-Dalgarno sequence. RNA Biol..
Fürtig B, Schnieders R, Richter C, Zetzsche H, Keyhani S, Helmling C, Kovacs H, Schwalbe H.  2016.  Direct 13C-detected NMR Experiments for Mapping and Characterization of Hydrogen Bonds in RNA. J. Biomol. NMR. 64(3):207-21.
Gande SL, Saxena K, Sreeramulu S, Linhard V, Kudlinzki D, Heinzlmeir S, Reichert AJ, Skerra A, Küster B, Schwalbe H.  2016.  Expression and purification of EPHA2 tyrosine kinase domain for crystallographic and NMR studies.. ChemBioChem. 17(23):2257-2263.
Kumar PY, Saha P, Saha D, Bessi I, Schwalbe H, Chowdhurz S, Dash J.  2016.  Fluorescent Dansyl-guanosine Conjugates That Bind c-MYC Promoter G-quadruplex and Down-regulate c-MYC Expression. Chembiochem. 17(5):388-93.
Kaushik M, Bahrenberg T, Can TV, Caporini MA, Silvers R, Heiliger J, Smith AA, Schwalbe H, Griffin RG, Corzilius B.  2016.  Gd(iii) and Mn(ii) complexes for dynamic nuclear polarization: small molecular chelate polarizing agents and applications with site-directed spin labeling of proteins.. Phys Chem Chem Phys. 18:27205-27218.
Daube D, Aladin V, Heiliger J, Wittmann J, Barthelmes D, Schwalbe H, Corzilius B.  2016.  Heteronuclear cross-relaxation under solid-state dynamic nuclear polarization. J. Am. Chem. Soc.. 138(51):16572-16575.
Thevarpadam' J, Bessi' I, Binas' O, Schmidt DG, Slavov C, Jonker HRA, Wachtveitl J, Schwalbe* H, Heckel* A.  2016.  Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif. Angew. Chem. Int. Ed.. 55(8):2738-42.
Henker J, Wirmer-Bartoschek J, Bendel LE, Xiang YG, Fu C, Harms K, Schwalbe H, Meggers E.  2016.  Progress in the synthesis and bioactivity of hexacoordinate silicon (IV) complexes. European Journal of Inorganic Chemistry. 32(5161-5170)
Zhu W, Silvers R, Schwalbe H, Keiderling T.  2016.  Reduced and mutant lysozyme refolding with lipid vesicles. Model study of impact of disulfides on equilibria and dynamics.. Biochim Biophys Acta. 1864(9):1083-92.
Debnath M, Ghosh S, Panda D, Bessi I, Schwalbe H, Bhattacharyya K, Dash J.  2016.  Small Molecule Regulated Dynamic Structural changes of Human G-quadruplexes. Chemical Science. 7:3279-3285.
Heering J, Jonker HRA, Löhr F, Schwalbe H, Dötsch V.  2016.  Structural investigations oft he p53/p73 homologs from the tunicate species Ciona intestinalis reveal the sequence requirements for the formation of a tetramerization domain. Protein Sci.. 25(2):410-22.
Buhr F, Jha S, Thommen M, Mittelstaet J, Kutz F, Schwalbe* H, Rodnina* M, Komar* A.  2016.  Synonymous codons direct co-translational folding towards different proteins conformations. Mol. Cell. 61(3):341-51.
Chauhan A, Paul R, Debnath M, Bessi I, Mandal S, Schwalbe H, Dash J.  2016.  Synthesis of Fluorescent Binaphthyl Amines That Bind c-MYC G-Quadruplex DNA and Repress c-MYC Expression.. J Med Chem. 59:7275-81.
Andernach L, Sandjo L, Liermann J, Schlämann R, Richter C, Ferner J-P, Schwalbe H, Schueffler A, Thines E, Opatz T.  2016.  Terphenyl Derivatives from Allantophomopsis lycopodina. J. Natural Product. 79:2718-2725.
Wirmer-Bartoschek J, Schwalbe H.  2016.  Understanding how DNA enzymes work. Angew. Chem. Int. Ed.. 55(18):5376-7.
2015
Nasiri HR, Ferner J, Tükek C, Krishnathas R, Schwalbe H.  2015.  A concise one-step synthesis of primin and iso-primin. Tetrahedron Lett.. 56:2231-2233.
Buhr F, Kohl-Landgraf J, tom Dieck S, Hanus C, Chatterjee D, Hegelein A, Schuman EM, Wachtveitl J, Schwalbe H.  2015.  Design of photocaged puromycin for nascent polypeptide release and spatiotemporal monitoring of translation. Angew. Chem. Intl. Ed.. 54:3717-21.
Silvers R, Keller H, Schwalbe H, Hengesbach M.  2015.  Differential Scanning Fluorimetry for Monitoring RNA Stability. ChemBioChem. 16:1109–1114.