Publications

Found 357 results

2014

Schwalbe H, Fürtig B. 2014. RNA refolding studied by light-coupled NMR spectroscopy.. Meth. Mol. Biol.. 1086:309-19.

Stehle J, Silvers R, Werner K, Chatterjee D, Gande S, Scholz F, Dutta A, Wachtveitl J, Klein-Seetharaman J, Schwalbe H. 2014. Solution NMR characterization of simultaneous meta II and meta III decay kinetics in rhodopsin. Angew. Chem. Int Ed Engl.. 53:2078-2084.

Hengesbach M, Schwalbe H. 2014. Structural Basis for Regulation of Ribosomal RNA 2'-O-Methylation. Angew. Chem. Int Ed Engl.. 53:1742-4.

Sripakdeevong P, Cevec M, Chang A, Erat M, Ziegeler M, Zhao Q, Fox G, Gao X, Kennedy S, Kierzek R et al.. 2014. Structure determination of noncanonical RNA motifs guided by 1H NMR chemical shifts. Nature Methods. 11:413-6.

2013

Bono F, De F, Herbert C, De K, Georgiadou M, Fons P, Tjwa M, Alcouffe C, Ny A, Bianciotto M et al.. 2013. Inhibition of Tumor Angiogenesis and Growth by a Small-Molecule Multi-FGF Receptor Blocker with Allosteric Properties. Cancer cell. 23(4):477-488. Abstract

Nasiri H, Madej G, Panisch R, Bats J, Lafontaine M, Lancaster CR, Schwalbe H. 2013. Design, Synthesis and Biological Testing of Novel Naphthoquinones as Substrate-Based Inhibitors of the Quinol:Fumarate Reductase from Wolinella succinogenes.. J. Med. Chem..

Silvers R, Schwalbe H. 2013. Detecting Intracellular Cysteine Redox States by in-Cell NMR Spectroscopy. ChemBioChem. 14:1705-1707.

Schweitzer-Stenner R, Hagarmann A, Toal S, Mathieu D, Schwalbe H. 2013. Disorder and order in unfolded and disordered peptides and proteins: A view derived from tripeptide conformational analysis. I. Tripeptides with long and predominantly hydrophobic side chains.. Proteins. 81:955-967.

Rybka K, Toal SE, D.J.Verbaro, Mathieu D, Schwalbe H, Schweizer-Stenner R. 2013. Disorder and order in unfolded and disordered peptides and proteins: A view derived from tripeptide conformational analysis. II. tripeptides with short side chains populating asx and β-type like turn conformations.. Proteins. 81:968-983.

Kumar YP, Bhowmik S, Das RN, Bessi I, Paladhi S, Ghosh R, Schwalbe H, Dash J. 2013. A fluorescent guanosine dinucleoside as a selective switch-on sensor for c-myc G-quadruplex DNA with potent anticancer activities. Chemistry - A European Journal. 19(35):11502-6.

Nielsen G, Jonker HRA, Vajpaj N, Grzesiek S, Schwalbe H. 2013. Kinase in motion: insights into the dynamic nature of p38alpha by high pressure NMR spectroscopic studies.. ChemBioChem. 14:1799-1806.

Schwalbe H, Telser J. 2013. Magnetic Resonance Spectroscopy in Bio(in)organic Chemistry and in Mechanistic SystemsBiology: A Tribute to Ivano Bertini. ChemBioChem. 14:1671-1675.

Schlepckow K, Schwalbe H. 2013. Molecular Mechanism of Prion Protein Oligomerization at Atomic Resolution. Angew. Chem. Int Ed Engl.. 52:10002-5.

Herbert C, Schieborr U, Saxena K, Juraszek J, Smet DF, Alcouffe C, Bianciotto M, Saladino G, Sibrac D, Kudlinzki D et al.. 2013. Molecular mechanism of SSR128129E, an extracellularly acting, small molecule, allosteric inhibitor of FGF receptor signaling. Cancer Cell . 23:489-501.

Schieborr U, Sreeramulu S, Elshorst B, Maurer M, Saxena K, Kudlinzki D, Gande S, Schwalbe H. 2013. MOTOR: Model assisted Software for NMR Structure Determination. Proteins. 81:2007-2022.

Lieblein AL, Fürtig B, Schwalbe H. 2013. Optimizing kinetics and thermodynamics of DNA i-motif folding. ChemBioChem. 14:1226-30.

Schwalbe H, Fürtig B. 2013. RNA refolding studied by light-coupled NMR spectroscopy. RNA folding: methods and protocols. 1086:309-319.

Guan J-Y, Keizers P, Liu W-M, Loehr F, Skinner S, Heeneman E, Schwalbe H, Ubbink M, Siegal G. 2013. Small molecule binding sites on proteins established by paramagnetic NMR spectroscopy. J. Am. Chem. Soc. 135:5859-68.

Hiruma Y, Hass MAS, Kikui Y, Liu W-M, Ölmez B, Skinner SP, Blok A, Kloosterman A, Koteishi H, Löhr F et al.. 2013. The Structure of the Cytochrome P450cam-Putidaredoxin Complex Determined by Paramagnetic NMR Spectroscopy and Crystallography. J. Mol. Biol.. 425:4353-4365.

Reining A, Nozinovic S, Schlepckow K, Buhr F, Fürtig* B, Schwalbe* H. 2013. Three-state mechanism couples ligand and temperature sensing in riboswitches. Nature. 499:355-359.

2012

Schieborr U, Saxena K, Elshorst B, Schwalbe H. 2012. 1H, 13C and 15N assignment of D2 domain of human fibroblast growth factor receptor 4. Biomolecular NMR Assignments.

Stehle T, Sreeramulu S, Löhr F, Richter C, Saxena K, Jonker HRA, Schwalbe H. 2012. The apo-structure of the low-molecular-weight protein tyrosine phosphatase A (MptpA) from Mycobacterium tuberculosis allows for better target-specific drug development. J. Biol. Chem.. 287(41):34569-82.

Rogne P, Ozdowy P, Richter C, Saxena K, Schwalbe H, Kuhn L. 2012. Atomic-level structure characterization of an ultrafast folding mini-protein denatured state. Plos One. 7(7):e41301.

Rosato A, Aramini JM, Arrowsmith C, Bagaria A, Baker D, Cavalli A, Doreleijers JF, Eletsky A, Giachetti A, Guerry P et al.. 2012. Blind testing of routine, fully automated determination of protein structures from NMR data. Structure. 20:227-236.

Stehle J, Scholz F, Löhr F, Reckel S, Roos C, Blum M, Braun M, Glaubitz C, Dötsch V, Wachtveitl J et al.. 2012. Characterization of the ground state dynamics of proteorhodopsin by NMR and Optical Spectroscopies. J. Biomol. NMR. 54(4):401-413.

Sziegat F, Silvers R, Hähnke M, Jensen M, Blackledge M, Wirmer-Bartoschek J, Schwalbe H. 2012. Disentangling the coil: Modulation of conformational and dynamic properties by site-directed mutation in non-native state of hen egg white lysozyme. Biochemistry. 51(16):3361-3372.

Fürtig B, Buck J, Richter C, Schwalbe H. 2012. Functional dynamics of RNA ribozymes studied by NMR spectroscopy. Ribozymes: Methods and Protocols. 848:185-199. Abstract

Steinert H, Rinnenthal J, Schwalbe H. 2012. Individual Basepair Stability of DNA and RNA studied by NMR-detected Solvent Exchange. Biophysical J.. 102(11):2564-74.

Verbaro DJ, Mathieu D, Toal SE, Schwalbe H, Schweitzer-Stenner R. 2012. Ionized Trilysine: A Model System for Understanding the Non-Random Structure of Poly-L-Lysine and Lysine-Containing Motifs in Proteins. J Phys Chem B. . 116(28):8084-8094.

Saxena K, Dutta A, Klein-Seetharaman J, Schwalbe H. 2012. Isotope labeling in insect cells. Methods Mol Biol.. 831:37-54..

Dutta A, Saxena K, Schwalbe H, Klein-Seetharaman J. 2012. Isotope labeling in mammalian cells. Methods Mol Biol.. 831:55-69.

Mathieu D, Rybka K, Graf J, Schwalbe H. 2012. Mapping conformational dynamics in unfolded polypeptide chains using short model peptides by NMR spectroscopy. Peptide Folding, Misfolding, and Nonfolding. :187-219.

Wacker A, Buck J, Richter C, Schwalbe H, Wöhnert J. 2012. Mechanisms for differentiation between cognate and near-cognate ligands by purine riboswitches. RNA Biology. 9(5):672-680.

Silvers R, Sziegat F, Tachibana H, Segawa S-ichi, Whittaker S, Günther U, Gabel F, Huang J-rong, Blackledge M, Wirmer-Bartoschek J et al.. 2012. Modulation of Structure and Dynamics by Disulfide Bond Formation in Unfolded States. J. Am. Chem. Soc.. 134(15):6846-54.

Lieblein AL, Krämer M, Dreuw A, Fürtig B, Schwalbe H. 2012. The nature of the hydrogen bonds in Cytidine-H+-Cytidine DNA base pairs. Angew. Chem. Int. Ed. . 51:4067-4070.

Schieborr U, Sreeramulu S, Schwalbe H. 2012. NMR structure determination of Protein-Ligand Complexes. NMR of Biomolecules: Towards Mechanistic Systems Biology. :549-561.

Ziegeler* M, Cevec* M, Richter C, Schwalbe H. 2012. NMR Studies of HAR1 RNA Secondary Structures Reveal Conformational Dynamics in the Human RNA. ChemBioChem. 13:2100-2112.

Cevec M, Jonker HRA, Nozinovic S, Richter C, Schwalbe H. 2012. Nucleic Acids. NMR of Biomolecules: Towards Mechanistic Systems Biology. :21-31.

Nielsen G, Schwalbe H. 2012. Protein NMR Spectroscopy: Hydrogen bonds under pressure. Nature Chemistry. 4(9):693-5.

Silvers R, Saxena K, Kudlinzki D, Schwalbe H. 2012. Recombinant expression and purification of human TATA binding protein using a chimeric fusion. Protein Expression and Purification. 85:142-147.

Ferner J-P, Ferner ED, Rinnenthal J, Buck J, Wöhnert J, Schwalbe H. 2012. RNA as a Drug Target. NMR of Biomolecules: Towards Mechanistic Systems Biology. :299-313.

Bessi I, Bazzicalupi C, Richter C, Jonker HRA, Saxena K, Sissi C, Chioccioli M, Bianco S, Bilia AR, Schwalbe H et al.. 2012. Spectroscopic, molecular modeling and NMR-spectroscopic investigation of the binding mode of the natural alkaloids berberine and sanguinarine to human telomeric G-quadruplex DNA. ACS Chemical Biology. 7(6):1109-1119.

Lieblein AL, Buck J, Schlepckow K, Fürtig B, Schwalbe H. 2012. Time-resolved NMR studies of DNA i-motif folding reveal kinetic partitioning. Angew. Chem.Intl. Ed. Engl.. 51:250-253.

Angerer H, Nasiri HR, Niedergesäß V, Kirscher S, Schwalbe H, Brandt U. 2012. Tracing the tail of ubiquinone in mitochondrial complex I. BBA Bioenergetics. 1817(10):1776-84.

2011

Nozinovic S, Gupta P, Fürtig B, Richter C, Tüllmann S, Ferner-Duchardt E, Holthausen M, Schwalbe H. 2011. 2'OH Group Conformation in RNA derived from NMR spectroscopy and DFT calculations. Angew. Chem. Intl. Ed. Engl.. 50(23):5397-400.

Hagarman A, Mathieu D, Toal S, Measey TJ, Schwalbe H, Schweitzer-Stenner R. 2011. Amino Acids with Hydrogen Bonding Side Chains have an Intrinsic Tendency to Sample Various Turn Conformations in Aqueous Solution. Chemistry - A European Journal. 17(24):6789-97.

Sziegat F, Wirmer-Bartoschek J, Schwalbe H. 2011. Characteristics of Human Lysozyme and Its Disease-Related Mutants in their Unfolded States. Angew. Chem. Intl. Ed. Engl.. 50:5514-8.

Schwalbe H. 2011. Commentary: Double Take on PiWi Protein/piRNA Complex Structure. Structure. 19(2):141-142.

katja Barthelmes, Reynolds A, Peizach E, Jonker HRA, Denunzio N, Allen K, Imperiali B, Schwalbe H. 2011. Engineering Encodable Lanthanide-Binding Tags (LBTs) into Loop Regions of Proteins. J. Am. Chem. Soc.. 133:808-819. Abstract

Buck J, Wacker A, Warkentin E, Wöhnert J, Wirmer-Bartoschek J, Schwalbe H. 2011. Influence of ground-state structure and Mg2+ binding on folding kinetics of the guanine-sensing riboswitch aptamer domain. Nucleic Acids Res.. 39:9768-9778.