Publications

Found 37 results

2023

Tannenberg R, Paul M, Röder B, Gande SL, Sreeramulu S, Saxena K, Richter C, Schwalbe H, Swart C, Weller MG. 2023. Chemiluminescence Biosensor for the Determination of Cardiac Troponin I (cTNI). Biosensors. 13:455.

Duchardt-Ferner E, Ferner J, Fürtig B, Hengesbach M, Richter C, Schlundt A, Sreeramulu S, Wacker A, Weigand JE, Wirmer-Bartoschek J et al.. 2023. COVID19-NMR consortium: A public report on the impact of this new global collaboration. Angew. Chem. Intl. Ed.. :e202217171.

Li Y, Pustovalova Y, Shi W, Gorbatyuk O, Sreeramulu S, Schwalbe H, Hoch JC, Hao B. 2023. Crystal structure of the CoV-Y domain of SARS-CoV-2 nonstructural protein 3.. Sci Rep.. 13(1):2890.

Tröster A, DiPrima M, Jores N, Kudlinzki D, Sreeramulu S, Gande SL, Linhard V, Ludig D, Schug A, Saxena K et al.. 2023. Optimization of the Lead Compound NVP-BHG712 as Colorectal Cancer Inhibitor. Chemistry - A European Journal.

2022

Tsika AC, Gallo A, Fourkiotis NK, Argyriou AI, Sreeramulu S, Löhr F, Rogov VV, Richter C, Linard V, Gande SL et al.. 2022. Binding adaptation of GS-441524 diversifies macro domains and downregulate SARS-CoV-2 de-MARylation capacity. J. Mol. Biol.. 434(16):167720.

Berg H, Martin WMA, Altincekic N, Alshamleh I, Bains KJ, Blechar J, Ceylan B, de Jesus V, Dhamotharan K, Fuks C et al.. 2022. Exploring the druggability of conserved RNA regulatory elements in the SARS-CoV-2 genome. Angew. Chem. Intl. Ed.. 61:e202205858.

Heering J, Jores N, Kilu W, Schallmayer E, Peelen E, Muehler A, Kohlhof H, Vitt D, Linhard V, Gande SL et al.. 2022. Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators . ACS CHem. Biol..

Niesteruk A, Sreeramulu S, Jonker HRA, Richter C, Schwalbe H. 2022. Oxidation of the Mycobacterium tuberculosis key virulence factor protein tyrosine phosphatase A (MptpA) reduces its phosphatase activity.. Febs Lett..

2021

Sreeramulu S, Richter C, Berg H, Martin WMA, Ceylan B, Matzel T, Adam J, Altincekic N, Azzaoui K, Bains KJ et al.. 2021. Exploring the druggability of conserved RNA regulatory elements in the SARS-CoV-2 genome. Angew. Chem. Int. Ed. Engl.. 60:19191-19200.

Altincekic N, Korn SM, Qureshi NS, Dujardin M, Ninot-Pedrosa M, Abele R, Saad AMJ, Alfano C, Almeida FCL, de Amorim CG et al.. 2021. Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications. Frontiers in Molecular Biosciences. 8:653148.

Ahmad UDM, Fish A, Molenaar J, Sreeramulu S, Richter C, Altincekic N, Schwalbe H, H.Wienk, Perrakis A. 2021. Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery. J. Vis. Exp.. 171:e62449.

Berg H, Martin WM, Niesteruk A, Richter C, Sreeramulu S, Schwalbe H. 2021. NMR-based fragment screening in a minimum sample but maximum automation mode. J. Vis. Exp.. :e62262.

Faudone G, Kilu W, Ni X, Chaikuad A, Sreeramulu S, Heitel P, Schwalbe H, Knapp S, Schubert-Zsilavecs M, Heering J et al.. 2021. The transcriptional repressor orphan nuclear receptor TLX is responsive to xanthines.. ACS Pharmacol. Transl. Sci.. 4:1794-1807.

2020

Kubatova N, Qureshi NS, Altincekic N, Abele R, Bains JK, Ceylan B, Ferner J, Fuks C, Hargittay B, Hutchison MT et al.. 2020. 1H, 13C, and 15N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10. Biomolecular NMR assignments.

Cantini F, Banci* L, Altincekic N, Bains JK, Dhamotharan K, Fuks C, Fürtig B, Gande SL, Hargittay B, Hengesbach M et al.. 2020. 1H, 13C, and 15N backbone chemical shift assignments of the apo and the ADP‑ribose bound forms of the macrodomain of SARS‑CoV‑2 non‑structural protein 3b. Biomolecular NMR assignments. 14(2):339-346.

Gallo A, Tsika AC, Fourkiotis NK, Cantini F, Banci L, Sreeramulu S, Schwalbe H, Spyroulias GA. 2020. 1H,13C, and 15N chemical shift assignments of the SUD domains of SARS-CoV-2 non-structural protein 3c: "The SUD-M and SUD-C domains". Biomolecular NMR assignments.

Schulte L, Mao J, Reitz J, Sreeramulu S, Kudlinzki D, Hordinau VV, Meier-Credo J, Saxena K, Buhr F, Langer JD et al.. 2020. Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. Nat Commun. . 11(1):5569.

Schlundt A, Martin WMA, Knezic B, Hengesbach M, Fürtig B, Weigand JE, Wöhnert J, Ferner J, Saxena K, Wacker A et al.. 2020. Gemeinschaftlich in Krisenzeiten: NMR-Strukturbiologie gegen COVID-19. BIOspektrum. 26:440-441.

Sreeramulu S, Richter C, Kühn T, Azzaoui K, Blommers MJJ, Conte DR, Fragai M, Trieloff N, Schmieder P, Nazaré M et al.. 2020. NMR Quality Control of Fragment Libraries for Screening. J. Biomol. NMR. 74:555-563.

Wenger KJ, Richter C, Burger MC, Urbans H, Kaulfuss S, Jarter PN, Sreeramulu S, Schwalbe H, Steinbach JP, Hattingen E et al.. 2020. Non-invasive measurement of drug a 2-HG signals using 19F and 1H MR spectroscopy in brain tumors treated with the mutant IDH1 inhibitor BAY1436032.. Cancers. 12:E3175.

Wacker A, Weigand JE, Akabayov S-R, Altincekic N, Bains JK, Banijamali E, Binas O, Castillo-Martínez J, Cetiner E, Ceylan B et al.. 2020. Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy. Nucl. Acids Res. 48(22):12415-12435.

Weigand JE, Ferner J, Fürtig B, Hacker C, Hähnke M, Hengesbach M, Richter C, Saxena K, Schlundt A, Sreeramulu S et al.. 2020. Strukturbiologie von SARS-CoV-2 mit NMR-Spektroskopie. Nachrichten aus Chemie und Technik. 68:55-58.

2019

Merk* D, Sreeramulu S, Kudlinzki D, Saxena K, Linhardt V, Gande SL, Hiller F, Lamers C, Nilsson E, Aagard A et al.. 2019. Molecular tuning of farnesoid X receptor partial agonism. Nature Comm.. 10(1):2915.

2018

Qureshi NS, Sreeramulu S, Bains JK, Schwalbe* H, Fürtig* B. 2018. Conformational switch in the ribosomal protein S1 guides unfolding of structured RNAs for translation initiation. Nucl. Acids Res.. 46:10917-10929.

Niesteruk A, Jonker HRA, Richter C, Linhardt V, Sreeramulu S, Schwalbe H. 2018. The domain architecture of the PtkA, the first tyrosine kinase from Mycobacterium tuberculosis differs from the conventional kinase architecture. J. Biol. Chem.. 293 :11823-11836.

Raab M, Sanhaji M, Pietsch L, Béquignon I, Herbrand AK, Süß E, Gande SL, Caspar B, Kudlinzki D, Saxena K et al.. 2018. Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds. ACS Chem Biol. 13:1921-1931.

Tröster A, Heinzlmeir S, Berger BT, Gande SL, Saxena K, Sreeramulu S, Linhard V, Nasiri AH, Bolte M, Müller S et al.. 2018. NVP-BHG712: Effects of regioisomers on the affinity and selectivity towards the EPHrin family. ChemMedChem. 13:2358-2464.

Wienen-Schmidt B, Wulsdorf T, Jonker HRA, Saxena K, Kudlinzki D, Linhard V, Sreeramulu S, Heine A, Schwalbe H, Klebe G. 2018. On the implication of water on fragment-to-ligand growth in kinase binding thermodynamics. ChemMedChem. 13:1988-1996.

Wienen-Schmidt B, Jonker HRA, Wulsdorf T, Gerber H-D, Saxena K, Kudlinzki D, Sreeramulu S, Parigi G, Luchinat C, Heine A et al.. 2018. Paradoxically, Most Flexible Ligand Binds Most Entropy-Favored: Intriguing Impact of Ligand Flexibility and Solvation on Drug-Kinase Binding. J. Med. Chem.. 61:5922-5933.

Kappert F, Sreeramulu S, Jonker HRA, Richter C, Rogov VV, Proschak E, Hargittay B, Saxena K, Schwalbe H. 2018. Structural Characterization of the Interaction of the Fibroblast Growth Factor Receptor with a Small Molecule Allosteric Inhibitor. Chemistry - A European Journal. 24:7861-7865.

Niesteruk A, Hutchison M, Sreeramulu S, Jonker HRA, Richter C, Abele R, Bock C, Schwalbe H. 2018. Structural characterization of the Intrinsically Disordered Domain (IDD) of Mycobacterium tuberculosis Protein Tyrosine Kinase A (PtkA). FEBS Lett.. 592(7):1233-1245.

2017

Heinzlmeir S, Lohse J, Treiber T, Kudlinzki D, Linhardt V, Gande SL, Sreeramulu S, Saxena K, Liu X, Wilhelm M et al.. 2017. Chemoproteomics-aided medicinal chemistry for the discovery of EPHA2 inhibitors. ChemMedChem. 12(12):999-1011.

2016

Heinzlmeir# S, Kudlinzki# D, Sreeramulu S, Klaeger S, Gande SL, Linhardt V, Wilhelm M, Qiao H, Helm D, Ruprecht B et al.. 2016. Chemical proteomics and structural biology define EPHA2 inhibition by clinical kinase drugs.. ACS Chem. Biol..

2015

Kudlinzki D, Linhard VL, Saxena K, Sreeramulu S, Gande S, Schieborr U, Dreyer M, Schwalbe H. 2015. High-resolution crystal structure of cAMP-dependent protein kinase from Cricetulus griseus.. Acta Crystallogr F Struct Biol Commun.. 71:1088-93.

Scharow A, Raab M, Saxena K, Sreeramulu S, Kudlinzki D, Gande S, Dötsch C, Kurunci-Csacsko E, Kläger S, Küster B et al.. 2015. Optimized Plk1 PBD inhibitors based on Poloxin induce mitotic arrest and apoptosis in tumor cells. ACS Chemical Biology. 10(11):2570-9.

2013

Herbert C, Schieborr U, Saxena K, Juraszek J, Smet DF, Alcouffe C, Bianciotto M, Saladino G, Sibrac D, Kudlinzki D et al.. 2013. Molecular mechanism of SSR128129E, an extracellularly acting, small molecule, allosteric inhibitor of FGF receptor signaling. Cancer Cell . 23:489-501.

Schieborr U, Sreeramulu S, Elshorst B, Maurer M, Saxena K, Kudlinzki D, Gande S, Schwalbe H. 2013. MOTOR: Model assisted Software for NMR Structure Determination. Proteins. 81:2007-2022.