Publications

Found 65 results

2024
Toews S, Wacker A, Faison E, Duchardt-Ferner E, Richter C, Mathieu D, Battaro S, Zhang Q, Schwalbe H.  2024.  The 5’-terminal stem-loop RNA element of SARS-CoV-2 features highly dynamic structural elements that are sensitive to differences in cellular pH. Nucl. Acids Res..
Krause NM, Bains JK, Blechar J, Richter C, Bessi I, Grote P, Leisegang MS, Brandes* RP, Schwalbe* H.  2024.  Biophysical investigation of RNA-DNA:DNA triple helix and RNA:DNA heteroduplex formation by the lncRNAs MEG3 and Fendrr. ChemBioChem.
Jalencas X, Berg H, Espeland LO, Sreeramulu S, Kinnen F, Richter C, Georgiou C, Yadrykhinsky V, Specker E, Jaudzems K et al..  2024.  Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection. RSC Med. Chem..
Mineev KS, Hargittay B, Jin J, Catapano C, Dietz MS, Segarra M, Harwardt MS, Richter C, Jonker HRA, Saxena K et al..  2024.  Differential effects of the N-terminal helix of FGF8b on the activity of a small-molecule FGFR inhibitor in cell culture and for the extracellular domain of FGFR3c in solution . FEBS Lett.
Becker MA, Meiser N, Schmidt-Dengler M, Richter C, Wacker* A, Schwalbe* H, Hengesbach* M.  2024.  m6A methylation of transcription leader sequence impacts discontinuous transcription of subgenomic mRNAs. . Chemistry - A European Jounal.
Matzel T, Martin WM, Herr A, Wacker A, Richter C, Sreeramulu S, Schwalbe H.  2024.  NMR characterization and ligand binding site of the stem loop 2 motif (s2m) from the Delta variant of SARS-CoV-2.. RNA. 30:779-794.
Altincekic* N, Jores N, Löhr F, Richter C, Ehrhardt C, Blommers MJJ, Berg H, Öztürk S, Gande SL, Linhard V et al..  2024.  Targeting main protease (Mpro, nsp5) by growth of fragment scaffolds exploiting structure-based methodologies. ACS Chem. Biol. . 19:563-574.
2023
Tannenberg R, Paul M, Röder B, Gande SL, Sreeramulu S, Saxena K, Richter C, Schwalbe H, Swart C, Weller MG.  2023.  Chemiluminescence Biosensor for the Determination of Cardiac Troponin I (cTNI). Biosensors. 13:455.
Duchardt-Ferner E, Ferner J, Fürtig B, Hengesbach M, Richter C, Schlundt A, Sreeramulu S, Wacker A, Weigand JE, Wirmer-Bartoschek J et al..  2023.  COVID19-NMR consortium: A public report on the impact of this new global collaboration. Angew. Chem. Intl. Ed.. :e202217171.
Oxenfarth A, Kümmerer F, Battaro S, Schnieders R, Pinter G, Jonker HRA, Fürtig B, Richter C, Blackledge M, Lindorff-Larsen K et al..  2023.  Integrated NMR/Molecular Dynamics Determination of the Ensemble Conformation of a thermodynamically stable CUUG RNA tetraloop. JACS. 145:16557-16572.
Hutchison M, Bellomo G, Cherepanov A, Stirnal E, Fürtig B, Richter C, Linhard V, Gurewitsch E, Lelli M, Morgner N et al..  2023.  Modulation of Aβ42 aggregation kinetics and pathway by low molecular weight inhibitors. ChemBioChem.
Hymon D, Martins J, Richter C, Sreeramulu S, Wacker A, Ferner J, Patwarhan NN, Hargroove AE, Schwalbe H.  2023.  NMR 1H, 19F-based screening of the four stem-looped structure 5_SL1-SL4 located in the 5’-untranslated region of SARS-CoV-2 RNA.. RSC Med. Chem. . 15:165-177.
2022
Mertinkus KR, Grün JT, Altincekic N, Bains KJ, Ceylan B, Ferner J-P, Frydman L, Fürtig B, Hengesbach M, Hohmann KF et al..  2022.  1H, 13C and 15N chemical shift assignment of the stem-loops 5b+c from the 5'-UTR of SARS-CoV-2. Biomolecular NMR Assignments. 16(1):17-25.
Tsika AC, Gallo A, Fourkiotis NK, Argyriou AI, Sreeramulu S, Löhr F, Rogov VV, Richter C, Linard V, Gande SL et al..  2022.  Binding adaptation of GS-441524 diversifies macro domains and downregulate SARS-CoV-2 de-MARylation capacity. J. Mol. Biol.. 434(16):167720.
Berg H, Martin WMA, Altincekic N, Alshamleh I, Bains KJ, Blechar J, Ceylan B, de Jesus V, Dhamotharan K, Fuks C et al..  2022.  Exploring the druggability of conserved RNA regulatory elements in the SARS-CoV-2 genome. Angew. Chem. Intl. Ed.. 61:e202205858.
Leisegang MS, Bains KJ, Seredinski S, Oo LA, Krause NM, Kuo C-C, Günther S, Cetin NS, Warwick T, Cao C et al..  2022.  HIF1alpha-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex. Nat. Commun. 13( 6563)
Niesteruk A, Sreeramulu S, Jonker HRA, Richter C, Schwalbe H.  2022.  Oxidation of the Mycobacterium tuberculosis key virulence factor protein tyrosine phosphatase A (MptpA) reduces its phosphatase activity.. Febs Lett..
2021
Vögele J, Ferner J-P, Altincekic N, Bains KJ, Ceylan B, Fürtig B, Grün JT, Hengesbach M, Hohmann KF, Hymon D et al..  2021.  1H, 13C, 15N and 31P chemical shift assignment for stem-loop 4 from the 5'-UTR of SARS-CoV-2. Biomolecular NMR assignments. 15:335-340.
Richter C, K. F. Hohmann, S. Toews MADN, Toews S, Mathieu D, Altincekic N, Bains KJ, Binas O, Ceylan B, Duchardt-Ferner E, Ferner J et al..  2021.  1H, 13C, and 15N Assignment of Stem-Loop SL1 from the 5'-UTR of SARS-CoV-2. Biomolecular NMR assignments. 15(2):467-474.
Schnieders R, Peters SA, Banijamali E, Riad M, Altincekic N, Bains JK, Ceylan B, Fürtig B, Grün JT, Hengesbach M et al..  2021.  1H, 13C, and 15N chemical shift assignments of the stem-loop 5a from the 5‘-UTR of SARS-CoV-2. Biomolecular NMR assignments.
Kim J, Novakovic M, Jayanthi S, Lupulescu A, Kupce E, Grün JT, Mertinkus K, Oxenfarth A, Richter C, Schnieders R et al..  2021.  3D Heteronuclear Magnetization Transfers for the establishment of secondary structures in SARS-CoV-2-derived RNAs. J. Am. Chem. Soc. 143:4942-4948.
Sreeramulu S, Richter C, Berg H, Martin WMA, Ceylan B, Matzel T, Adam J, Altincekic N, Azzaoui K, Bains KJ et al..  2021.  Exploring the druggability of conserved RNA regulatory elements in the SARS-CoV-2 genome. Angew. Chem. Int. Ed. Engl.. 60:19191-19200.
Müller D, Bessi I, Richter C, Schwalbe H.  2021.  The folding landscapes of human telomeric RNA and DNA G-quadruplexes are markedly different.. Angew. Chem. Int. Ed. Engl.. 60(19):10895-10901.
Altincekic N, Korn SM, Qureshi NS, Dujardin M, Ninot-Pedrosa M, Abele R, Saad AMJ, Alfano C, Almeida FCL, de Amorim CG et al..  2021.  Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications. Frontiers in Molecular Biosciences. 8:653148.
Novakovic M, Kupce E, Scherf T, Oxenfarth A, Schnieders R, Grün T, Wirmer-Bartoschek J, Richter C, Schwalbe H, Frydman L.  2021.  Magnetization transfer to enhance NOE cross-peaks among labile protons: Applications to imino-imino sequential walks in SARS-CoV-2-derived RNAs. Anew. Chem. Int. Ed. Engl.. 60:11884-11891.
Ahmad UDM, Fish A, Molenaar J, Sreeramulu S, Richter C, Altincekic N, Schwalbe H, H.Wienk, Perrakis A.  2021.  Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery. J. Vis. Exp.. 171:e62449.
Berg H, Martin WM, Niesteruk A, Richter C, Sreeramulu S, Schwalbe H.  2021.  NMR-based fragment screening in a minimum sample but maximum automation mode. J. Vis. Exp.. :e62262.
2020
Kubatova N, Qureshi NS, Altincekic N, Abele R, Bains JK, Ceylan B, Ferner J, Fuks C, Hargittay B, Hutchison MT et al..  2020.  1H, 13C, and 15N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10. Biomolecular NMR assignments.
Cantini F, Banci* L, Altincekic N, Bains JK, Dhamotharan K, Fuks C, Fürtig B, Gande SL, Hargittay B, Hengesbach M et al..  2020.  1H, 13C, and 15N backbone chemical shift assignments of the apo and the ADP‑ribose bound forms of the macrodomain of SARS‑CoV‑2 non‑structural protein 3b. Biomolecular NMR assignments. 14(2):339-346.
Korn SM, Dhamotharan K, Fürtig B, Hengesbach M, Löhr F, Qureshi NS, Richter C, Saxena K, Schwalbe H, Tants JN et al..  2020.  1H, 13C, and 15N backbone chemical shift assignments of the nucleic acid-binding domain of SARS-CoV-2 non-structural protein 3e. Biomolecular NMR assignments. Biomolecular NMR assignments.
Schlundt A, Martin WMA, Knezic B, Hengesbach M, Fürtig B, Weigand JE, Wöhnert J, Ferner J, Saxena K, Wacker A et al..  2020.  Gemeinschaftlich in Krisenzeiten: NMR-Strukturbiologie gegen COVID-19. BIOspektrum. 26:440-441.
Sreeramulu S, Richter C, Kühn T, Azzaoui K, Blommers MJJ, Conte DR, Fragai M, Trieloff N, Schmieder P, Nazaré M et al..  2020.  NMR Quality Control of Fragment Libraries for Screening. J. Biomol. NMR. 74:555-563.
Schnieders R, Knezic B, Zetzsche H, Sudakov A, Matzel T, Richter C, Hengesbach M, Schwalbe H, Fürtig B.  2020.  NMR spectroscopy of large functional RNAs - from sample preparation to low-gamma-detection. Current protocols in Nucl. Acids. 82(e116)
Wenger KJ, Richter C, Burger MC, Urbans H, Kaulfuss S, Jarter PN, Sreeramulu S, Schwalbe H, Steinbach JP, Hattingen E et al..  2020.  Non-invasive measurement of drug a 2-HG signals using 19F and 1H MR spectroscopy in brain tumors treated with the mutant IDH1 inhibitor BAY1436032.. Cancers. 12:E3175.
Aslamleh I, Krause N, Richter C, Kurrle N, Serve H, Günther UL, Schwalbe H.  2020.  Real-time NMR for studying metabolism. Angew. Chem. Int. Ed. Engl.. 59(6):2304-2308.
Wacker A, Weigand JE, Akabayov S-R, Altincekic N, Bains JK, Banijamali E, Binas O, Castillo-Martínez J, Cetiner E, Ceylan B et al..  2020.  Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy. Nucl. Acids Res. 48(22):12415-12435.
Altincekic N, Löhr M, Meier-Credo J, Langer J, Hengesbach M, Richter C, Schwalbe H.  2020.  Site-specific detection of arginine methylation in highly repetitive protein motifs of low sequence complexity by NMR. J. Am. Chem. Soc. 142(16):7647-7654.
Zhou S, Ruan M, Li Y, Yang J, Bai S, Richter C, Schwalbe H, Xie C, Shen B, Wang J.  2020.  Solution structure of the voltage-gated Tim23 channel in complex with a mitochondrial presequence peptide . Cell Res.
Weigand JE, Ferner J, Fürtig B, Hacker C, Hähnke M, Hengesbach M, Richter C, Saxena K, Schlundt A, Sreeramulu S et al..  2020.  Strukturbiologie von SARS-CoV-2 mit NMR-Spektroskopie. Nachrichten aus Chemie und Technik. 68:55-58.
2019
Shi YN, Pusch S, Shi YM, Richter C, Macia-Vicente JG, Schwalbe H, Kaiser M, Opatz T, Bode HB.  2019.  (±) Alternarlactones A and B, two antiparasitic alternariol-like dimers from the fungus Alternaria alternate P1210 isolated from the halophyte Salicornia sp.. J. Org. Chem.. 84(17):11203-11209.
Schnieders R, Wolter AC, Richter C, Wöhnert J, Schwalbe* H, Fürtig* B.  2019.  Novel 13C-detected NMR experiments for precise detection of RNA structure. Angew. Chem. Int. Ed.. 58(27):9140-9144.
Kubatova N, Pyper DJ, Jonker HRA, Saxena K, Remmel L, Richter C, Brantl S, Evguenieva-Hackenberg E, Hess W, Klug G et al..  2019.  Rapid biophysical characterization and NMR structural analysis ofsmall proteins from bacteria and archaea. ChemBioChem.
Kubatova N, Jonker HRA, Saxena K, Richter C, Vogel V, Schreiber S, Marchfelder A, Schwalbe H.  2019.  Solution structure and dynamics of the small protein HVO_2922 from Haloferax volcanii. ChemBioChem. 21(1-2):149-156.
2018
Niesteruk A, Jonker HRA, Richter C, Linhardt V, Sreeramulu S, Schwalbe H.  2018.  The domain architecture of the PtkA, the first tyrosine kinase from Mycobacterium tuberculosis differs from the conventional kinase architecture. J. Biol. Chem.. 293 :11823-11836.
Coutinho ID, Henning LMM, Döpp SA, Mepomuceno A, Morales LAC, Marcolino-Gomes J, Richter C, Schwalbe H, Colnago LA.  2018.  Flooded soybean metabolomic analysis reveals important primary and secondary metabolites involved in the hypoxia stress response and tolerance. Environmental and Experimental Biology. 153:176-187.
Shi YM, Richter C, Challinor VL, Grün P, GirelaDelRio A, Kaiser M, SChüffler A, Piepenbring M, Schwalbe H, Bode HB.  2018.  Georatusin, a Specific Antiparasitic Polyketide-Peptide Hybrid from the Fungus Geomyces auratus. Org Lett. 20:1563-1567.
Coutinho ID, Henning LMM, Döpp SA, Nepomuceno A, Moraes LAC, Marcolino-Gomes J, Richter C, Schwalbe H, Colnago LA.  2018.  Identification of primary and secondary metabolites and transcriptome profile of soybean tissues during different stages of hypoxia. Data Brief. 21:1089-1100.
Muthukumar Y, Münkemer J, Mathieu D, Richter C, Schwalbe H, Steinmetz H, Kessler W, Reichelt J, Beutling U, Frank R et al..  2018.  Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria. PLOS One. 13:e0201605.
Joedicke L, Mao J, Kuenze G, Reinhart C, Kalavacherla T, Jonker HRA, Richter C, Schwalbe H, Meiler J, Preu J et al..  2018.  The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.. Nat. Chem. Biol.. 14:284-290.
Kappert F, Sreeramulu S, Jonker HRA, Richter C, Rogov VV, Proschak E, Hargittay B, Saxena K, Schwalbe H.  2018.  Structural Characterization of the Interaction of the Fibroblast Growth Factor Receptor with a Small Molecule Allosteric Inhibitor. Chemistry - A European Journal. 24:7861-7865.