Publications

Found 11 results

2024
Altincekic* N, Jores N, Löhr F, Richter C, Ehrhardt C, Blommers MJJ, Berg H, Öztürk S, Gande SL, Linhard V et al..  2024.  Targeting main protease (Mpro, nsp5) by growth of fragment scaffolds exploiting structure-based methodologies. ACS Chem. Biol. . 19:563-574.
2023
Kunert S, Linhard V, Weidrich S, Choudalakis M, Osswald F, Krämer L, Köhler AR, Bröhm A, Wollenhaupt J, Schwalbe H et al..  2023.  The MECP2-TRD domain interacts with the DNMT3A-ADD domain at the H3-tail binding site. Protein Sci. 32(1):e4542.
Hutchison M, Bellomo G, Cherepanov A, Stirnal E, Fürtig B, Richter C, Linhard V, Gurewitsch E, Lelli M, Morgner N et al..  2023.  Modulation of Aβ42 aggregation kinetics and pathway by low molecular weight inhibitors. ChemBioChem.
Tröster A, DiPrima M, Jores N, Kudlinzki D, Sreeramulu S, Gande SL, Linhard V, Ludig D, Schug A, Saxena K et al..  2023.  Optimization of the Lead Compound NVP-BHG712 as Colorectal Cancer Inhibitor. Chemistry - A European Journal.
2022
Berg H, Martin WMA, Altincekic N, Alshamleh I, Bains KJ, Blechar J, Ceylan B, de Jesus V, Dhamotharan K, Fuks C et al..  2022.  Exploring the druggability of conserved RNA regulatory elements in the SARS-CoV-2 genome. Angew. Chem. Intl. Ed.. 61:e202205858.
Heering J, Jores N, Kilu W, Schallmayer E, Peelen E, Muehler A, Kohlhof H, Vitt D, Linhard V, Gande SL et al..  2022.  Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators . ACS CHem. Biol..
2021
Altincekic N, Korn SM, Qureshi NS, Dujardin M, Ninot-Pedrosa M, Abele R, Saad AMJ, Alfano C, Almeida FCL, de Amorim CG et al..  2021.  Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications. Frontiers in Molecular Biosciences. 8:653148.
2020
Kubatova N, Qureshi NS, Altincekic N, Abele R, Bains JK, Ceylan B, Ferner J, Fuks C, Hargittay B, Hutchison MT et al..  2020.  1H, 13C, and 15N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10. Biomolecular NMR assignments.
Cantini F, Banci* L, Altincekic N, Bains JK, Dhamotharan K, Fuks C, Fürtig B, Gande SL, Hargittay B, Hengesbach M et al..  2020.  1H, 13C, and 15N backbone chemical shift assignments of the apo and the ADP‑ribose bound forms of the macrodomain of SARS‑CoV‑2 non‑structural protein 3b. Biomolecular NMR assignments. 14(2):339-346.
2018
Tröster A, Heinzlmeir S, Berger BT, Gande SL, Saxena K, Sreeramulu S, Linhard V, Nasiri AH, Bolte M, Müller S et al..  2018.  NVP-BHG712: Effects of regioisomers on the affinity and selectivity towards the EPHrin family. ChemMedChem. 13:2358-2464.
Wienen-Schmidt B, Wulsdorf T, Jonker HRA, Saxena K, Kudlinzki D, Linhard V, Sreeramulu S, Heine A, Schwalbe H, Klebe G.  2018.  On the implication of water on fragment-to-ligand growth in kinase binding thermodynamics. ChemMedChem. 13:1988-1996.