Publications

Found 35 results

2024
Mineev KS, Hargittay B, Jin J, Catapano C, Dietz MS, Segarra M, Harwardt MS, Richter C, Jonker HRA, Saxena K et al..  2024.  Differential effects of the N-terminal helix of FGF8b on the activity of a small-molecule FGFR inhibitor in cell culture and for the extracellular domain of FGFR3c in solution . FEBS Lett.
2023
Tannenberg R, Paul M, Röder B, Gande SL, Sreeramulu S, Saxena K, Richter C, Schwalbe H, Swart C, Weller MG.  2023.  Chemiluminescence Biosensor for the Determination of Cardiac Troponin I (cTNI). Biosensors. 13:455.
Tröster A, DiPrima M, Jores N, Kudlinzki D, Sreeramulu S, Gande SL, Linhard V, Ludig D, Schug A, Saxena K et al..  2023.  Optimization of the Lead Compound NVP-BHG712 as Colorectal Cancer Inhibitor. Chemistry - A European Journal.
2022
Berg H, Martin WMA, Altincekic N, Alshamleh I, Bains KJ, Blechar J, Ceylan B, de Jesus V, Dhamotharan K, Fuks C et al..  2022.  Exploring the druggability of conserved RNA regulatory elements in the SARS-CoV-2 genome. Angew. Chem. Intl. Ed.. 61:e202205858.
2021
Altincekic N, Korn SM, Qureshi NS, Dujardin M, Ninot-Pedrosa M, Abele R, Saad AMJ, Alfano C, Almeida FCL, de Amorim CG et al..  2021.  Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications. Frontiers in Molecular Biosciences. 8:653148.
2020
Kubatova N, Qureshi NS, Altincekic N, Abele R, Bains JK, Ceylan B, Ferner J, Fuks C, Hargittay B, Hutchison MT et al..  2020.  1H, 13C, and 15N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10. Biomolecular NMR assignments.
Cantini F, Banci* L, Altincekic N, Bains JK, Dhamotharan K, Fuks C, Fürtig B, Gande SL, Hargittay B, Hengesbach M et al..  2020.  1H, 13C, and 15N backbone chemical shift assignments of the apo and the ADP‑ribose bound forms of the macrodomain of SARS‑CoV‑2 non‑structural protein 3b. Biomolecular NMR assignments. 14(2):339-346.
Korn SM, Dhamotharan K, Fürtig B, Hengesbach M, Löhr F, Qureshi NS, Richter C, Saxena K, Schwalbe H, Tants JN et al..  2020.  1H, 13C, and 15N backbone chemical shift assignments of the nucleic acid-binding domain of SARS-CoV-2 non-structural protein 3e. Biomolecular NMR assignments. Biomolecular NMR assignments.
Zahn S, Kubatova N, Pyper DJ, L. Cassidy, Saxena K, Tholey A, Schwalbe H, Soppa J.  2020.  Biological functions, genetic and biochemical characterization, and NMR structure determination of the small zinc finger protein HVO_2753 from Haloferax volcanii. Febs J..
Schulte L, Mao J, Reitz J, Sreeramulu S, Kudlinzki D, Hordinau VV, Meier-Credo J, Saxena K, Buhr F, Langer JD et al..  2020.  Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. Nat Commun. . 11(1):5569.
Chiapparino A, Grbavac A, Jonker HR, Hackmann Y, Mortensen S, Zatorska E, Schott A, Stier G, Saxena K, Wild K et al..  2020.  Functional implications of MIR domains in protein O-mannosylation. eLife. 9:e61189.
Schlundt A, Martin WMA, Knezic B, Hengesbach M, Fürtig B, Weigand JE, Wöhnert J, Ferner J, Saxena K, Wacker A et al..  2020.  Gemeinschaftlich in Krisenzeiten: NMR-Strukturbiologie gegen COVID-19. BIOspektrum. 26:440-441.
Kubatova N, Mao J, Eckert CE, Saxena K, Gande SL, Wachtveitl* J, Glaubitz* C, Schwalbe* H.  2020.  Light dynamics of retinal disease-relevant G90D bovine rhodopsin mutant. Angew. Chem. Int. Ed. Engl.. 59:15656–15664.
Jonker HRA, Saxena K, Shcherbakova A, Tiemann B, Bakker H, Schwalbe H.  2020.  NMR characterization of the C-mannose conformation in a trombospondin repeat using a selective labeling approach. Angew. Chem. Int. Ed. Engl..
Wacker A, Weigand JE, Akabayov S-R, Altincekic N, Bains JK, Banijamali E, Binas O, Castillo-Martínez J, Cetiner E, Ceylan B et al..  2020.  Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy. Nucl. Acids Res. 48(22):12415-12435.
Weigand JE, Ferner J, Fürtig B, Hacker C, Hähnke M, Hengesbach M, Richter C, Saxena K, Schlundt A, Sreeramulu S et al..  2020.  Strukturbiologie von SARS-CoV-2 mit NMR-Spektroskopie. Nachrichten aus Chemie und Technik. 68:55-58.
2019
Merk* D, Sreeramulu S, Kudlinzki D, Saxena K, Linhardt V, Gande SL, Hiller F, Lamers C, Nilsson E, Aagard A et al..  2019.  Molecular tuning of farnesoid X receptor partial agonism. Nature Comm.. 10(1):2915.
Kubatova N, Pyper DJ, Jonker HRA, Saxena K, Remmel L, Richter C, Brantl S, Evguenieva-Hackenberg E, Hess W, Klug G et al..  2019.  Rapid biophysical characterization and NMR structural analysis ofsmall proteins from bacteria and archaea. ChemBioChem.
Kubatova N, Jonker HRA, Saxena K, Richter C, Vogel V, Schreiber S, Marchfelder A, Schwalbe H.  2019.  Solution structure and dynamics of the small protein HVO_2922 from Haloferax volcanii. ChemBioChem. 21(1-2):149-156.
2018
Raab M, Sanhaji M, Pietsch L, Béquignon I, Herbrand AK, Süß E, Gande SL, Caspar B, Kudlinzki D, Saxena K et al..  2018.  Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds. ACS Chem Biol. 13:1921-1931.
Tröster A, Heinzlmeir S, Berger BT, Gande SL, Saxena K, Sreeramulu S, Linhard V, Nasiri AH, Bolte M, Müller S et al..  2018.  NVP-BHG712: Effects of regioisomers on the affinity and selectivity towards the EPHrin family. ChemMedChem. 13:2358-2464.
Wienen-Schmidt B, Wulsdorf T, Jonker HRA, Saxena K, Kudlinzki D, Linhard V, Sreeramulu S, Heine A, Schwalbe H, Klebe G.  2018.  On the implication of water on fragment-to-ligand growth in kinase binding thermodynamics. ChemMedChem. 13:1988-1996.
Wienen-Schmidt B, Jonker HRA, Wulsdorf T, Gerber H-D, Saxena K, Kudlinzki D, Sreeramulu S, Parigi G, Luchinat C, Heine A et al..  2018.  Paradoxically, Most Flexible Ligand Binds Most Entropy-Favored: Intriguing Impact of Ligand Flexibility and Solvation on Drug-Kinase Binding. J. Med. Chem.. 61:5922-5933.
Kappert F, Sreeramulu S, Jonker HRA, Richter C, Rogov VV, Proschak E, Hargittay B, Saxena K, Schwalbe H.  2018.  Structural Characterization of the Interaction of the Fibroblast Growth Factor Receptor with a Small Molecule Allosteric Inhibitor. Chemistry - A European Journal. 24:7861-7865.
2017
Heinzlmeir S, Lohse J, Treiber T, Kudlinzki D, Linhardt V, Gande SL, Sreeramulu S, Saxena K, Liu X, Wilhelm M et al..  2017.  Chemoproteomics-aided medicinal chemistry for the discovery of EPHA2 inhibitors. ChemMedChem. 12(12):999-1011.
2016
Nasiri AH, Saxena K, Bats JW, Nasiri HR, Schwalbe H.  2016.  Biophysical investigation and conformational analysis of p38α kinase inhibitor doramapimod and its analogues. MedChemCom. 7:1421-1428.
Heinzlmeir# S, Kudlinzki# D, Sreeramulu S, Klaeger S, Gande SL, Linhardt V, Wilhelm M, Qiao H, Helm D, Ruprecht B et al..  2016.  Chemical proteomics and structural biology define EPHA2 inhibition by clinical kinase drugs.. ACS Chem. Biol..
2015
Baldus-Becker J, Bamann C, Saxena K, Gustmann H, Brown LJ, Brown RC, Reiter C, Bamberg E, Wachtveitl J, Schwalbe H et al..  2015.  Enlightening the photoactive site of channelrhodopsin-2 by DNP-enhanced solid-state NMR spectroscopy. Proc Natl Acad Sci USA. 112(32):9896-901.
Kudlinzki D, Linhard VL, Saxena K, Sreeramulu S, Gande S, Schieborr U, Dreyer M, Schwalbe H.  2015.  High-resolution crystal structure of cAMP-dependent protein kinase from Cricetulus griseus.. Acta Crystallogr F Struct Biol Commun.. 71:1088-93.
D.Chatterjee, Eckert CE, Slavov C, Saxena K, Fürtig B, Sanders CR, Gurevich VV, Wachtveitl J, Schwalbe H.  2015.  Influence of arrestin on the photodecay of bovine rhodopsin. Angew, Chem. Int. Ed.. 54:13555-13560.
Scharow A, Raab M, Saxena K, Sreeramulu S, Kudlinzki D, Gande S, Dötsch C, Kurunci-Csacsko E, Kläger S, Küster B et al..  2015.  Optimized Plk1 PBD inhibitors based on Poloxin induce mitotic arrest and apoptosis in tumor cells. ACS Chemical Biology. 10(11):2570-9.
Saxena K, Schwalbe H.  2015.  The role of NMR in target identification and validation for pharmaceutical R&D. 4:305-314..
2013
Herbert C, Schieborr U, Saxena K, Juraszek J, Smet DF, Alcouffe C, Bianciotto M, Saladino G, Sibrac D, Kudlinzki D et al..  2013.  Molecular mechanism of SSR128129E, an extracellularly acting, small molecule, allosteric inhibitor of FGF receptor signaling. Cancer Cell . 23:489-501.
Schieborr U, Sreeramulu S, Elshorst B, Maurer M, Saxena K, Kudlinzki D, Gande S, Schwalbe H.  2013.  MOTOR: Model assisted Software for NMR Structure Determination. Proteins. 81:2007-2022.
2012
Saxena K, Dutta A, Klein-Seetharaman J, Schwalbe H.  2012.  Isotope labeling in insect cells. Methods Mol Biol.. 831:37-54..