Publications

Found 208 results

2024
Lala B, Chaudhuri R, Prasanth T, Burkhart I, Schwalbe H, Dash J.  2024.  Guanosine-based hydrogel as a supramolecular scaffold for template-assisted macrocylization. Chem. Commun. . 60:3433-3436.
Matzel T, Martin WM, Herr A, Wacker A, Richter C, Sreeramulu S, Schwalbe H.  2024.  NMR characterization and ligand binding site of the stem loop 2 motif (s2m) from the Delta variant of SARS-CoV-2.. RNA.
Ugrina M, Burkhart I, Müller D, Schwalbe H, Schwierz N.  2024.  RNA G-quadruplex folding is a multi-pathway process driven by conformational entropy. Nucl. Acids Res.. 52:87-100.
Vögele J, Duchardt-Ferner E, Bains JK, Knezic B, Wacker A, Sich C, Weigand J, Sponer J, Schwalbe H, Krepl M et al..  2024.  Structure of an internal loop motif with three consecutive U•U mismatches from stem-loop 1 in the 3'-UTR of the SARS-CoV-2 genomic RNA. Nucl. Acids Res..
Altincekic* N, Jores N, Löhr F, Richter C, Ehrhardt C, Blommers MJJ, Berg H, Öztürk S, Gande SL, Linhard V et al..  2024.  Targeting main protease (Mpro, nsp5) by growth of fragment scaffolds exploiting structure-based methodologies. ACS Chem. Biol. . 19:563-574.
2023
Bains KJ, Qureshi N, Ceylan B, Wacker A, Schwalbe H.  2023.  Cell-free transcription-translation system – A dual read-out assay to characterize riboswitch function. Nucl. Acids Res. 51, e82. Nucl. Acids Res.. 51:e82.
Üresin D, Pyper DJ, Borst A, Hadjeres L, Gelhausen R, Backofen R, Sharma C, Schwalbe H, Soppa J.  2023.  Characterization of the zinc finger µ-protein HVO_0758 from Haloferax volcanii: biological roles, zinc binding, and NMR solution structure. Frontiers in Microbiology. 14:120972.
Tannenberg R, Paul M, Röder B, Gande SL, Sreeramulu S, Saxena K, Richter C, Schwalbe H, Swart C, Weller MG.  2023.  Chemiluminescence Biosensor for the Determination of Cardiac Troponin I (cTNI). Biosensors. 13:455.
Duchardt-Ferner E, Ferner J, Fürtig B, Hengesbach M, Richter C, Schlundt A, Sreeramulu S, Wacker A, Weigand JE, Wirmer-Bartoschek J et al..  2023.  COVID19-NMR consortium: A public report on the impact of this new global collaboration. Angew. Chem. Intl. Ed.. :e202217171.
Li Y, Pustovalova Y, Shi W, Gorbatyuk O, Sreeramulu S, Schwalbe H, Hoch JC, Hao B.  2023.  Crystal structure of the CoV-Y domain of SARS-CoV-2 nonstructural protein 3.. Sci Rep.. 13(1):2890.
Ali T, Rogala S, Krause N, Bains KJ, Melissari M-T, Währisch S, Schwalbe H, Herrmann BG, Grothe P.  2023.  Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA Triplex Element. Nucl. Acids Res.
Vögele J, Hymon D, Martins J, Ferner J, Jonker HRA, Hargrove AE, Wacker A, Schwalbe H, Wöhnert J, Duchardt-Ferner E.  2023.  High-resolution structure of stem-loop 4 from the 5'-UTR of SARS-CoV-2 solved by solution state NMR. Nucl. Acids Res.. 51:11318-11331.
Grün JT, Kim J, Jayanthi S, Lupulescu A, Kupče ER, Schwalbe H, Frydman L.  2023.  Identifying and Overcoming Artifacts in 1H-Based Saturation Transfer NOE NMR Experiments. J. Am. Chem. Soc..
Oxenfarth A, Kümmerer F, Battaro S, Schnieders R, Pinter G, Jonker HRA, Fürtig B, Richter C, Blackledge M, Lindorff-Larsen K et al..  2023.  Integrated NMR/Molecular Dynamics Determination of the Ensemble Conformation of a thermodynamically stable CUUG RNA tetraloop. JACS. 145:16557-16572.
Cherepanov AV, Schwalbe H.  2023.  Large Temperature-Jump and Nanosecond Hyperquenching for Time-Resolve Structural Studies. Chemistry Method.
Kunert S, Linhard V, Weidrich S, Choudalakis M, Osswald F, Krämer L, Köhler AR, Bröhm A, Wollenhaupt J, Schwalbe H et al..  2023.  The MECP2-TRD domain interacts with the DNMT3A-ADD domain at the H3-tail binding site. Protein Sci. 32(1):e4542.
Hutchison M, Bellomo G, Cherepanov A, Stirnal E, Fürtig B, Richter C, Linhard V, Gurewitsch E, Lelli M, Morgner N et al..  2023.  Modulation of Aβ42 aggregation kinetics and pathway by low molecular weight inhibitors. ChemBioChem.
Hymon D, Martins J, Richter C, Sreeramulu S, Wacker A, Ferner J, Patwarhan NN, Hargroove AE, Schwalbe H.  2023.  NMR 1H, 19F-based screening of the four stem-looped structure 5_SL1-SL4 located in the 5’-untranslated region of SARS-CoV-2 RNA.. RSC Med. Chem. . 15:165-177.
Tröster A, DiPrima M, Jores N, Kudlinzki D, Sreeramulu S, Gande SL, Linhard V, Ludig D, Schug A, Saxena K et al..  2023.  Optimization of the Lead Compound NVP-BHG712 as Colorectal Cancer Inhibitor. Chemistry - A European Journal.
Alshamleh I, Kurrle N, Makowka P, Bhayadia R, Kumar R, Süsser S, Seibert M, Ludig D, Wolf S, Koschade SE et al..  2023.  PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia. Leukemia. 37:2367-2382.
Sudakov A, Knezic B, Hengesbach M, Fürtig B, Stirnal E, Schwalbe H.  2023.  Site-Specific Labeling of RNAs with Modified and 19F-Labelled Nucleotides by Chemo-Enzymatic Synthesis. Chemistry.
2022
Mertinkus KR, Grün JT, Altincekic N, Bains KJ, Ceylan B, Ferner J-P, Frydman L, Fürtig B, Hengesbach M, Hohmann KF et al..  2022.  1H, 13C and 15N chemical shift assignment of the stem-loops 5b+c from the 5'-UTR of SARS-CoV-2. Biomolecular NMR Assignments. 16(1):17-25.
Cunningham A, Erdem A, Alshamleh I, Geugien M, Pruis M, Pereira-Martins DA, van den Heuvel F, Wierenga A, Berge THA, Dennebos R et al..  2022.  Dietary methionine starvation impairs acute myeloid leukemia progression. Blood.
Berg H, Martin WMA, Altincekic N, Alshamleh I, Bains KJ, Blechar J, Ceylan B, de Jesus V, Dhamotharan K, Fuks C et al..  2022.  Exploring the druggability of conserved RNA regulatory elements in the SARS-CoV-2 genome. Angew. Chem. Intl. Ed.. 61:e202205858.
Kim J, Novakovic M, Jayanthi S, Lupulescu A, Kupce E, Grün T, Mertinkus K, Oxenfarth A, Schwalbe H, Frydman L.  2022.  The Extended Hadamard Transform: Sensitivity-Enhanced NMR Experiments Among Labile and Non-Labile 1Hs of SARS-CoV-2-derived RNAs. ChemPhysChem.
Knezic B, Keyhani-Goldau S, Schwalbe H.  2022.  Mapping the conformational landscape of the neutral network of RNA sequences that connect two functional distinctly different ribozymes. ChemBioChem. 23(7):e202200022.
Niesteruk A, Sreeramulu S, Jonker HRA, Richter C, Schwalbe H.  2022.  Oxidation of the Mycobacterium tuberculosis key virulence factor protein tyrosine phosphatase A (MptpA) reduces its phosphatase activity.. Febs Lett..
Schamber T, Binas O, Schlundt A, Wacker A, Schwalbe H.  2022.  Structure and Dynamics of the Guanidine-II Riboswitch from Escherichia coli by NMR Spectroscopy and Small-angle X-ray Scattering (SAXS). ChemBioChem. 23:e20210056410.
Warwick T, Serendinski S, Krause NM, Bains KJ, LAthaus L, Oo JA, Bonetti A, Dueck A, Engelhardt S, Schwalbe H et al..  2022.  A universal model of RNA.DNA:DNA triplex formation accurately predicts genome-wide RNA-DNA interactions . Brief Bioinform. bbac445
2021
Vögele J, Ferner J-P, Altincekic N, Bains KJ, Ceylan B, Fürtig B, Grün JT, Hengesbach M, Hohmann KF, Hymon D et al..  2021.  1H, 13C, 15N and 31P chemical shift assignment for stem-loop 4 from the 5'-UTR of SARS-CoV-2. Biomolecular NMR assignments. 15:335-340.
Salvi N, Bessa LM, Guseva S, Camcho-Zarco A, Maurin D, Perez LM, Hengesbach M, Korn SM, Schlundt A, Schwalbe H et al..  2021.  1H, 13C, and 15N backbone chemical shift assignments of SARS-CoV-2 Nsp3a. Biomolecular NMR assignments. 15:173-176.
Wang Y, Kirkpatrick J, zur Lage S, Korn SM, Neißner K, Schwalbe H, Schlundt A, Carlomagno T.  2021.  1H, 13C, and 15N backbone chemical-shift assignments of SARS-CoV-2 non-structural protein 1 (leader protein). Biomolecular NMR assignments. 15:287-295.
Schnieders R, Peters SA, Banijamali E, Riad M, Altincekic N, Bains JK, Ceylan B, Fürtig B, Grün JT, Hengesbach M et al..  2021.  1H, 13C, and 15N chemical shift assignments of the stem-loop 5a from the 5‘-UTR of SARS-CoV-2. Biomolecular NMR assignments.
Kim J, Novakovic M, Jayanthi S, Lupulescu A, Kupce E, Grün JT, Mertinkus K, Oxenfarth A, Richter C, Schnieders R et al..  2021.  3D Heteronuclear Magnetization Transfers for the establishment of secondary structures in SARS-CoV-2-derived RNAs. J. Am. Chem. Soc. 143:4942-4948.
Dudás FE, Puglisi R, Korn SM, Alfano C, Bellone ML, Piaz FD, Kelly G, Monaca E, Schlundt A, Schwalbe H et al..  2021.  Backbone chemical shift spectral assignments of SARS coronavirus-2 non-structural protein nsp9.. Biomolecular NMR assignments. 15:235-241.
Sreeramulu S, Richter C, Berg H, Martin WMA, Ceylan B, Matzel T, Adam J, Altincekic N, Azzaoui K, Bains KJ et al..  2021.  Exploring the druggability of conserved RNA regulatory elements in the SARS-CoV-2 genome. Angew. Chem. Int. Ed. Engl.. 60:19191-19200.
Grün JT, Schwalbe H.  2021.  Folding Dynamics of Polymorphic G-Quadruplex Structures. Biopolymers.
Müller D, Bessi I, Richter C, Schwalbe H.  2021.  The folding landscapes of human telomeric RNA and DNA G-quadruplexes are markedly different.. Angew. Chem. Int. Ed. Engl.. 60(19):10895-10901.
Gutt M, Jordan B, Weidenbach K, Gudzuhn M, Kiessling C, Cassidy L, Helbig A, Tholey A, Pyper DJ, Kubatova N et al..  2021.  High complexity of Glutamine synthetase regulation in Methanosarcina mazei: Small protein 26 interacts and enhances glutamine synthetase activity. FEBS J.. 288:5350-5373.
Wienk H, Banci L, Daenke S, Pereiro E, Schwalbe H, Stuart DI, Weiss MS, Perrakis A.  2021.  iNEXT-Discovery and Instrcut-ERIC: Integrating High-End Services for Translational Research in Structural Biology. J. Vis. Exp..
Mueller D, Saha P, Panda D, Dash J, Schwalbe H.  2021.  Insights from Binding on Quadruplex Selective Carbazole Ligands. Chemistry - A European Journal.
Altincekic N, Korn SM, Qureshi NS, Dujardin M, Ninot-Pedrosa M, Abele R, Saad AMJ, Alfano C, Almeida FCL, de Amorim CG et al..  2021.  Large-scale recombinant production of the SARS-CoV-2 proteome for high-throughput and structural biology applications. Frontiers in Molecular Biosciences. 8:653148.
Novakovic M, Kupce E, Scherf T, Oxenfarth A, Schnieders R, Grün T, Wirmer-Bartoschek J, Richter C, Schwalbe H, Frydman L.  2021.  Magnetization transfer to enhance NOE cross-peaks among labile protons: Applications to imino-imino sequential walks in SARS-CoV-2-derived RNAs. Anew. Chem. Int. Ed. Engl.. 60:11884-11891.
Grund TM, Radloff M, Wu D, Goojani HG, Witte KF, Jösting W, Buschmann S, Müller H, Elamri I, Welsch S et al..  2021.  Mechanistic and structural diversity between cytochrome bd isoforms of Escherichia coli. Proc. Nat. Acad. Sci. U.S.A. . 118
Baker F, Polat IH, Abou-Al-Ardat K, Alshamleh I, Thoelken M, Hymon D, Gubas A, Koschade SE, Vischedyk JB, Kaulich M et al..  2021.  Metabolic rewiring is essential for AML cell survival to overcome autophagy inhibition by loss of ATG3. Cancer.
Ahmad UDM, Fish A, Molenaar J, Sreeramulu S, Richter C, Altincekic N, Schwalbe H, H.Wienk, Perrakis A.  2021.  Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery. J. Vis. Exp.. 171:e62449.
Knezic B, Binas O, Völklein A, Schwalbe H.  2021.  NMR spectroscopic investigations of ribozymes. Ribozymes.
Berg H, Martin WM, Niesteruk A, Richter C, Sreeramulu S, Schwalbe H.  2021.  NMR-based fragment screening in a minimum sample but maximum automation mode. J. Vis. Exp.. :e62262.
Bocedi A, Cattani G, Gambardella G, Schulte L, Schwalbe H, Ricci G.  2021.  Oxidative Folding of Proteins: The "Smoking Gun" of Glutathione. Int. Journal of Mol. Science. 22:10148.
Harkness R, Hennecker C, Grün JT, Blümler A, Heckel A, Schwalbe H, Mittermaier A.  2021.  Parallel reaction pathways accelerate folding of a guanine quadruplex.. Nucl. Acids Res. 49:1247-1262.