Publications

Found 323 results

2015
Saxena K, Schwalbe H.  2015.  The role of NMR in target identification and validation for pharmaceutical R&D. 4:305-314..
Bruns N, Collisi W, Bernecker S, Stadler M, Richter C, Schwalbe H, Kalesse M.  2015.  Spirangien Derivatives from the Myxobacterium Sorangium cellulosum: Isolation, Structure Elucidation, and Biological Activity. European Journal of Organic Chemistry. 4:847-857.
Chatterjee D, Kudlinzki D, Linhard V, Saxena K, Schieborr U, Gande SL, Wurm JP, Wöhnert J, Abele R, Rogov VV et al..  2015.  Structure and Biophysical Characterization of the S-adenosylmethionine Dependent O-methyltransferase PaMTH1, a Putative Enzyme Accumulating during Senescence of Podospora anserina. J. Biol. Chem.. 290:16415-30.
Schimming O, Challinor VL, Tobias NJ, Adihou H, Grün P, Pöschel L, Richter C, Schwalbe H, Bode HB.  2015.  Structure, Biosynthesis, and Occurence of Bacterial Pyrrolizidine Alkaloids. Angew. Chem. Intl. Ed.. 54:12702-5.
Rinnenthal J, Wagner D, Marquardsen T, Krahn A, Engelke F, Schwalbe H.  2015.  A temperature-jump NMR probe setup using rf heating optimized for the analysis of temperature-induced biomacromolecular kinetics processes. J. Magn. Reson.. 251C:84-93.
Lannes L, Halder S, Krishnan Y, Schwalbe H.  2015.  Tuning the pH-response of i-motif DNA oligonucleotides. ChemBioChem. 16(11):1647-56.
Özçoban C, Halbritter T, Steinwand S, Herzig L-M, Kohl-Landgraf J, Askari N, Groher F, Fuertig B, Richter C, Schwalbe H et al..  2015.  Water-Soluble Py-BIPS Spiropyrans as Photoswitches for Biological Applications. Organic Letters. 17(6):1517-20.
2014
Schwalbe H.  2014.  Author Profile Harald Schwalbe. Angew. Chem. Int Ed Engl.. 53:10576–10577.
Fürtig B, Reining A, Sochor F, Oberhauser EM, Heckel A, Schwalbe H.  2014.  Characterization of the conformational dynamics of bistable RNAs by equilibrium and non-equilibrium NMR methods. Current Protocols in Nucleic Acid Chemistry. 55
Schilder J, Löhr F, Schwalbe H, Ubbink M.  2014.  The cytochrome c peroxidase and cytochrome c encounter complex: The other side of the story; see also: corrigendum: FEBS Lett. (2015) 589, 2169.. FEBS Lett.. 588(10):1873-8.
Zeiger M, Stark S, Kalden E, Ackermann B, Ferner J, Scheffer U, Shoja-Bazargani F, Erdel V, Schwalbe H, Göbel MW.  2014.  Fragment-based search for small molecule inhibitors of HIV-1 Tat-TAR. Bioorg Med Chem Lett.. 24:5576-80.
Nozinovic S, Reining A, Kim Y-B, Noeske J, Schlepckow K, Wöhnert J, Schwalbe H.  2014.  The importance of helix P1 stability for structural pre-organization and ligand binding affinity of the adenine riboswitch aptamer domain. RNA Biology. 11(5):655-666.
Steinert H, Schäfer F, Jonker HRA, Heckel A, Schwalbe H.  2014.  Influence of the absolute configuration of NPE-caged cytosine on DNA single base pair stability. Angew. Chem. Int Ed Engl.. 53:1072-1075..
Kohl-Landgraf J, Buhr F, Lefrancois D, Mewes J-M, Schwalbe H, Dreuw A, Wachtveitl J.  2014.  Mechanism of the Photoinduced Uncaging Reaction of Puromycin Protected by a 6-Nitroveratryloxycarbonyl Group. J. Am. Chem. Soc.. 136:3430-3438.
Helmling C, Bessi I, Wacker A, Schnorr KA, Jonker HRA, Richter C, Wagner D, Kreibich M, Schwalbe H.  2014.  Non - covalent spin labeling of riboswitch RNAs to obtain long-range structural NMR restraints. ACS Chem. Biol.. 9 (6):1330–133.
Rehbein P, Saxena K, Schlepckow K, Schwalbe H.  2014.  Protocol for aerosol-free recombinant production and NMR analysis of prion proteins. J. Biomol. NMR. 59:111-117.
Schwalbe H, Fürtig B.  2014.  RNA refolding studied by light-coupled NMR spectroscopy.. Meth. Mol. Biol.. 1086:309-19.
Stehle J, Silvers R, Werner K, Chatterjee D, Gande S, Scholz F, Dutta A, Wachtveitl J, Klein-Seetharaman J, Schwalbe H.  2014.  Solution NMR characterization of simultaneous meta II and meta III decay kinetics in rhodopsin. Angew. Chem. Int Ed Engl.. 53:2078-2084.
Hengesbach M, Schwalbe H.  2014.  Structural Basis for Regulation of Ribosomal RNA 2'-O-Methylation. Angew. Chem. Int Ed Engl.. 53:1742-4.
Sripakdeevong P, Cevec M, Chang A, Erat M, Ziegeler M, Zhao Q, Fox G, Gao X, Kennedy S, Kierzek R et al..  2014.  Structure determination of noncanonical RNA motifs guided by 1H NMR chemical shifts. Nature Methods. 11:413-6.
2013
Bono F, De F, Herbert C, De K, Georgiadou M, Fons P, Tjwa M, Alcouffe C, Ny A, Bianciotto M et al..  2013.  Inhibition of Tumor Angiogenesis and Growth by a Small-Molecule Multi-FGF Receptor Blocker with Allosteric Properties. Cancer cell. 23(4):477-488. Abstract
Nasiri H, Madej G, Panisch R, Bats J, Lafontaine M, Lancaster CR, Schwalbe H.  2013.  Design, Synthesis and Biological Testing of Novel Naphthoquinones as Substrate-Based Inhibitors of the Quinol:Fumarate Reductase from Wolinella succinogenes.. J. Med. Chem..
Silvers R, Schwalbe H.  2013.  Detecting Intracellular Cysteine Redox States by in-Cell NMR Spectroscopy. ChemBioChem. 14:1705-1707.
Schweitzer-Stenner R, Hagarmann A, Toal S, Mathieu D, Schwalbe H.  2013.  Disorder and order in unfolded and disordered peptides and proteins: A view derived from tripeptide conformational analysis. I. Tripeptides with long and predominantly hydrophobic side chains.. Proteins. 81:955-967.
Rybka K, Toal SE, D.J.Verbaro, Mathieu D, Schwalbe H, Schweizer-Stenner R.  2013.  Disorder and order in unfolded and disordered peptides and proteins: A view derived from tripeptide conformational analysis. II. tripeptides with short side chains populating asx and β-type like turn conformations.. Proteins. 81:968-983.
Kumar YP, Bhowmik S, Das RN, Bessi I, Paladhi S, Ghosh R, Schwalbe H, Dash J.  2013.  A fluorescent guanosine dinucleoside as a selective switch-on sensor for c-myc G-quadruplex DNA with potent anticancer activities. Chemistry - A European Journal. 19(35):11502-6.
Nielsen G, Jonker HRA, Vajpaj N, Grzesiek S, Schwalbe H.  2013.  Kinase in motion: insights into the dynamic nature of p38alpha by high pressure NMR spectroscopic studies.. ChemBioChem. 14:1799-1806.
Schwalbe H, Telser J.  2013.  Magnetic Resonance Spectroscopy in Bio(in)organic Chemistry and in Mechanistic SystemsBiology: A Tribute to Ivano Bertini. ChemBioChem. 14:1671-1675.
Schlepckow K, Schwalbe H.  2013.  Molecular Mechanism of Prion Protein Oligomerization at Atomic Resolution. Angew. Chem. Int Ed Engl.. 52:10002-5.
Herbert C, Schieborr U, Saxena K, Juraszek J, Smet DF, Alcouffe C, Bianciotto M, Saladino G, Sibrac D, Kudlinzki D et al..  2013.  Molecular mechanism of SSR128129E, an extracellularly acting, small molecule, allosteric inhibitor of FGF receptor signaling. Cancer Cell . 23:489-501.
Schieborr U, Sreeramulu S, Elshorst B, Maurer M, Saxena K, Kudlinzki D, Gande S, Schwalbe H.  2013.  MOTOR: Model assisted Software for NMR Structure Determination. Proteins. 81:2007-2022.
Lieblein AL, Fürtig B, Schwalbe H.  2013.  Optimizing kinetics and thermodynamics of DNA i-motif folding. ChemBioChem. 14:1226-30.
Schwalbe H, Fürtig B.  2013.  RNA refolding studied by light-coupled NMR spectroscopy. RNA folding: methods and protocols. 1086:309-319.
Guan J-Y, Keizers P, Liu W-M, Loehr F, Skinner S, Heeneman E, Schwalbe H, Ubbink M, Siegal G.  2013.  Small molecule binding sites on proteins established by paramagnetic NMR spectroscopy. J. Am. Chem. Soc. 135:5859-68.
Hiruma Y, Hass MAS, Kikui Y, Liu W-M, Ölmez B, Skinner SP, Blok A, Kloosterman A, Koteishi H, Löhr F et al..  2013.  The Structure of the Cytochrome P450cam-Putidaredoxin Complex Determined by Paramagnetic NMR Spectroscopy and Crystallography. J. Mol. Biol.. 425:4353-4365.
Reining A, Nozinovic S, Schlepckow K, Buhr F, Fürtig* B, Schwalbe* H.  2013.  Three-state mechanism couples ligand and temperature sensing in riboswitches. Nature. 499:355-359.
2012
Schieborr U, Saxena K, Elshorst B, Schwalbe H.  2012.  1H, 13C and 15N assignment of D2 domain of human fibroblast growth factor receptor 4. Biomolecular NMR Assignments.
Stehle T, Sreeramulu S, Löhr F, Richter C, Saxena K, Jonker HRA, Schwalbe H.  2012.  The apo-structure of the low-molecular-weight protein tyrosine phosphatase A (MptpA) from Mycobacterium tuberculosis allows for better target-specific drug development. J. Biol. Chem.. 287(41):34569-82.
Rogne P, Ozdowy P, Richter C, Saxena K, Schwalbe H, Kuhn L.  2012.  Atomic-level structure characterization of an ultrafast folding mini-protein denatured state. Plos One. 7(7):e41301.
Rosato A, Aramini JM, Arrowsmith C, Bagaria A, Baker D, Cavalli A, Doreleijers JF, Eletsky A, Giachetti A, Guerry P et al..  2012.  Blind testing of routine, fully automated determination of protein structures from NMR data. Structure. 20:227-236.
Stehle J, Scholz F, Löhr F, Reckel S, Roos C, Blum M, Braun M, Glaubitz C, Dötsch V, Wachtveitl J et al..  2012.  Characterization of the ground state dynamics of proteorhodopsin by NMR and Optical Spectroscopies. J. Biomol. NMR. 54(4):401-413.
Sziegat F, Silvers R, Hähnke M, Jensen M, Blackledge M, Wirmer-Bartoschek J, Schwalbe H.  2012.  Disentangling the coil: Modulation of conformational and dynamic properties by site-directed mutation in non-native state of hen egg white lysozyme. Biochemistry. 51(16):3361-3372.
Fürtig B, Buck J, Richter C, Schwalbe H.  2012.  Functional dynamics of RNA ribozymes studied by NMR spectroscopy. Ribozymes: Methods and Protocols. 848:185-199. Abstract
Steinert H, Rinnenthal J, Schwalbe H.  2012.  Individual Basepair Stability of DNA and RNA studied by NMR-detected Solvent Exchange. Biophysical J.. 102(11):2564-74.
Verbaro DJ, Mathieu D, Toal SE, Schwalbe H, Schweitzer-Stenner R.  2012.  Ionized Trilysine: A Model System for Understanding the Non-Random Structure of Poly-L-Lysine and Lysine-Containing Motifs in Proteins. J Phys Chem B. . 116(28):8084-8094.
Saxena K, Dutta A, Klein-Seetharaman J, Schwalbe H.  2012.  Isotope labeling in insect cells. Methods Mol Biol.. 831:37-54..
Dutta A, Saxena K, Schwalbe H, Klein-Seetharaman J.  2012.  Isotope labeling in mammalian cells. Methods Mol Biol.. 831:55-69.
Mathieu D, Rybka K, Graf J, Schwalbe H.  2012.  Mapping conformational dynamics in unfolded polypeptide chains using short model peptides by NMR spectroscopy. Peptide Folding, Misfolding, and Nonfolding. :187-219.
Wacker A, Buck J, Richter C, Schwalbe H, Wöhnert J.  2012.  Mechanisms for differentiation between cognate and near-cognate ligands by purine riboswitches. RNA Biology. 9(5):672-680.
Silvers R, Sziegat F, Tachibana H, Segawa S-ichi, Whittaker S, Günther U, Gabel F, Huang J-rong, Blackledge M, Wirmer-Bartoschek J et al..  2012.  Modulation of Structure and Dynamics by Disulfide Bond Formation in Unfolded States. J. Am. Chem. Soc.. 134(15):6846-54.