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G-quadruplexes are important drug targets in anticancer research. In our group, we apply NMR spectroscopy to investigate structural polymorphism of G-quadruplexes as well as real-time NMR to gain insight into folding pathways (Bessi et al., Angew Chem 2015). Further, we solve NMR structures of the holo and apo states of physiologically relevant G quadruplex drug targets (Wirmer-Bartoschek et al., Angew Chem 2017), and we apply state-of-the-art NMR methods to investigate G4-ligand interactions (Bessi et al., ACS Chem Biol. 2012).