Title | The concept of a random coil: Residual structure in peptides and denatured proteins |
Publication Type | Journal Article |
Year of Publication | 1996 |
Authors | Smith LJ, Fiebig KM, Schwalbe H, Dobson CM |
Journal | Folding and Design |
Volume | 1 |
Issue | 5 |
Pagination | R95 - R106 |
Date Published | 1996/10// |
Accession Number | 23 |
Abstract | Non-native states of proteins are of increasing interest because of their relevance to issues such as protein folding, translocation and stability. A framework for interpreting the wealth of experimental data for non-native states emerging from rapid advances in experimental techniques involves comparison with a [`]random coil' state, which possesses no structure except that inherent in the local interactions. We review here the concept of a random coil, from its global to its local properties. In particular, we focus on the description of a random coil in terms of statistical distributions in [phi], [psi] space. We show that such a model, in combination with experimental data, provides insight into the structural properties of polypeptide chains and has significance for understanding protein folding and for molecular design. |
URL | http://www.sciencedirect.com/science/article/B7W5X-4GK1D5S-1/2/6407468326465ebe4d16590107dfe78b |