Title | Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Ferner J, Suhartono M, Breitung S, Jonker HRA, Hennig M, Wöhnert J, Göbel M, Schwalbe H |
Journal | Chembiochem |
Volume | 10 |
Pagination | 1490–1494 |
Date Published | Jun |
Accession Number | 173 |
Abstract | Target TAR by NMR: Tripeptides containing arginines as terminal residues and non-natural amino acids as central residues are good leads for drug design to target the HIV trans-activation response element (TAR). The structural characterization of the RNA-ligand complex by NMR spectroscopy reveals two specific binding sites that are located at bulge residue U23 and around the pyrimidine-stretch U40-C41-U42 directly adjacent to the bulge. |
URL | http://dx.doi.org/10.1002/cbic.200900220 |
DOI | 10.1002/cbic.200900220 |