Publications

Found 29 results

2016

Gande SL, Saxena K, Sreeramulu S, Linhard V, Kudlinzki D, Heinzlmeir S, Reichert AJ, Skerra A, Küster B, Schwalbe H. 2016. Expression and purification of EPHA2 tyrosine kinase domain for crystallographic and NMR studies.. ChemBioChem. 17(23):2257-2263.

2015

Chatterjee D, Kudlinzki D, Linhard V, Saxena K, Schieborr U, Gande SL, Wurm JP, Wöhnert J, Abele R, Rogov VV et al.. 2015. Structure and Biophysical Characterization of the S-adenosylmethionine Dependent O-methyltransferase PaMTH1, a Putative Enzyme Accumulating during Senescence of Podospora anserina. J. Biol. Chem.. 290:16415-30.

2014

Rehbein P, Saxena K, Schlepckow K, Schwalbe H. 2014. Protocol for aerosol-free recombinant production and NMR analysis of prion proteins. J. Biomol. NMR. 59:111-117.

2012

Schieborr U, Saxena K, Elshorst B, Schwalbe H. 2012. 1H, 13C and 15N assignment of D2 domain of human fibroblast growth factor receptor 4. Biomolecular NMR Assignments.

Stehle T, Sreeramulu S, Löhr F, Richter C, Saxena K, Jonker HRA, Schwalbe H. 2012. The apo-structure of the low-molecular-weight protein tyrosine phosphatase A (MptpA) from Mycobacterium tuberculosis allows for better target-specific drug development. J. Biol. Chem.. 287(41):34569-82.

Rogne P, Ozdowy P, Richter C, Saxena K, Schwalbe H, Kuhn L. 2012. Atomic-level structure characterization of an ultrafast folding mini-protein denatured state. Plos One. 7(7):e41301.

Dutta A, Saxena K, Schwalbe H, Klein-Seetharaman J. 2012. Isotope labeling in mammalian cells. Methods Mol Biol.. 831:55-69.

Silvers R, Saxena K, Kudlinzki D, Schwalbe H. 2012. Recombinant expression and purification of human TATA binding protein using a chimeric fusion. Protein Expression and Purification. 85:142-147.

Bessi I, Bazzicalupi C, Richter C, Jonker HRA, Saxena K, Sissi C, Chioccioli M, Bianco S, Bilia AR, Schwalbe H et al.. 2012. Spectroscopic, molecular modeling and NMR-spectroscopic investigation of the binding mode of the natural alkaloids berberine and sanguinarine to human telomeric G-quadruplex DNA. ACS Chemical Biology. 7(6):1109-1119.

2010

Saxena K, Schieborr U, Anderka O, Duchardt-Ferner E, Elshorst B, Gande SL, Janzon J, Kudlinzki D, Sreeramulu S, Dreyer MK et al.. 2010. Influence of heparin mimetics on the assembly of the FGF - FGFR4 signaling complex. J. Biol. Chem.. 285:26628-26640. Abstract

2008

Betz M, Vogtherr M, Schieborr U, Elshorst B, Grimme S, Pescatore B, Langer T, Saxena K, Schwalbe H. 2008. Chemical Biology of Kinases Studied by NMR Spectroscopy. Chemical Biology. :852-890. Abstract

Nören-Müller A, Wilk W, Saxena K, Schwalbe H, Kaiser M, Waldmann H. 2008. Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis.. Angew Chem Int Ed Engl. 47:5973–5977.

2007

Corrêa IR, Nören-Müller A, Ambrosi H-D, Jakupovic S, Saxena K, Schwalbe H, Kaiser M, Waldmann H. 2007. Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS).. Chem Asian J. 2:1109–1126. Abstract

2006

Landrieu I, Lacosse L, Leroy A, Wieruszeski J-M, Trivelli X, Sillen A, Sibille N, Schwalbe H, Saxena K, Langer T et al.. 2006. NMR analysis of a Tau phosphorylation pattern.. J Am Chem Soc. 128:3575–3583. Abstract

Betz M, Saxena K, Schwalbe H. 2006. Biomolecular NMR: a chaperone to drug discovery.. Curr Opin Chem Biol. 10:219–225. Abstract

Vogtherr M, Saxena K, Hoelder S, Grimme S, Betz M, Schieborr U, Pescatore B, Robin M, Delarbre L, Langer T et al.. 2006. NMR characterization of kinase p38 dynamics in free and ligand-bound forms.. Angew Chem Int Ed Engl. 45:993–997.

Müller D, Krick A, Kehraus S, Mehner C, Hart M, Küpper FC, Saxena K, Prinz H, Schwalbe H, Janning P et al.. 2006. Brunsvicamides A-C: sponge-related cyanobacterial peptides with Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory activity.. J Med Chem. 49:4871–4878. Abstract

Nören-Müller A, Reis-Corrêa I, Prinz H, Rosenbaum C, Saxena K, Schwalbe HJ, Vestweber D, Cagna G, Schunk S, Schwarz O et al.. 2006. Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis. Proceedings of the National Academy of Sciences. 103(28):10606-10611. Abstract

Betz M, Vogtherr M, Schieborr U, Elshorst B, Grimme S, Pescatore B, Langer T, Saxena K, Schwalbe H. 2006. Chemical Biology of Kinases Studied by NMR Spectroscopy. Chemical Biology - From Small Molecules to Systems Biology and Drug Design.

Jacobs DM, Langer T, Elshorst B, Saxena K, Fiebig KM, Vogtherr M, Schwalbe H. 2006. NMR backbone assignment of the N-terminal domain of human HSP90.. J Biomol NMR. 36 Suppl 1:52.

2005

Saxena K, Elshorst B, Berk H, Betz M, Grimme S, Langer T, Pescatore B, Schieborr U, Vogtherr M, Schwalbe H. 2005. Backbone NMR assignment of the low-molecular-weight protein tyrosine phosphatase (MPtpA) from Mycobacterium tuberculosis.. J Biomol NMR. 33:136.

Manger M, Scheck M, Prinz H, von Kries JP, Langer T, Saxena K, Schwalbe H, Fürstner A, Rademann J, Waldmann H. 2005. Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase A (MptpA) inhibitors based on natural products and a fragment-based approach.. Chembiochem. 6:1749–1753.

Schieborr U, Vogtherr M, Elshorst B, Betz M, Grimme S, Pescatore B, Langer T, Saxena K, Schwalbe H. 2005. How much NMR data is required to determine a protein-ligand complex structure? Chembiochem. 6:1891–1898. Abstract

Vogtherr M, Saxena K, Grimme S, Betz M, Schieborr U, Pescatore B, Langer T, Schwalbe H. 2005. NMR backbone assignment of the mitogen-activated protein (MAP) kinase p38.. J Biomol NMR. 32:175.

Sreeramulu S, Kumar J, Richter C, Vogtherr M, Saxena K, Langer T, Schwalbe H. 2005. 1H, 13C and 15N backbone resonance assignment of the Hsp90 binding domain of human Cdc37.. J Biomol NMR. 32:262.

Jacobs DM, Grimme S, Elshorst B, Pescatore B, Vogtherr M, Betz M, Schieborr U, Langer T, Saxena K, Schwalbe H et al.. 2005. Backbone NMR assignment of the C-terminal haemopexin-like domain (HPLD) of human matrix metalloproteinase MMP-13.. J Biomol NMR. 32:337.

Saxena K, Jacobs DM, Vogtherr M, Grimme S, Elshort B, Pescatore B, Betz M, Schieborr U, Langer T, Schwalbe H et al.. 2005. Backbone NMR assignment of the human E2 ubiquitin conjugating enzyme UbcH5alpha (F72K,F82S) double mutant.. J Biomol NMR. 32:338.

Langer T, Sreeramulu S, Vogtherr M, Elshorst B, Betz M, Schieborr U, Saxena K, Schwalbe H. 2005. Folding and activity of cAMP-dependent protein kinase mutants.. FEBS Lett. 579:4049–4054. Abstract

2004

Langer T, Vogtherr M, Elshorst B, Betz M, Schieborr U, Saxena K, Schwalbe H. 2004. NMR backbone assignment of a protein kinase catalytic domain by a combination of several approaches: application to the catalytic subunit of cAMP-dependent protein kinase.. Chembiochem. 5:1508–1516. Abstract